Colorectal Tumour Microsatellite Instability Test Results: Perspectives from Patients

被引：4

作者：

Noralane M Lindor

Jeff Sloan

Richard Goldberg

Deborah Bowen

Sandra Nigon

Amber Roche

Gloria Petersen

Stephen N Thibodeau

Laurence Burgart

Olga Leontovich

Bruce W Morlan

机构：

[1] Department of Medical Genetics, Mayo Foundation, Rochester, MN

[2] Department of Biostatistics, Mayo Foundation, Rochester, MI

[3] Department of Oncology, Mayo Foundation, Rochester, MI

[4] Public Health Sciences Fred Hutchinson Cancer Research Center, Seattle, WA

[5] Department of Epidemiology, Mayo Foundation, Rochester, MI

[6] Department of Laboratory Medicine and Pathology, Mayo Foundation, Rochester, MI

[7] Department of Cancer Center Statistics, Mayo Foundation, Rochester, MI

来源：

Hereditary Cancer in Clinical Practice | / 2卷 / 2期

基金：

美国国家卫生研究院;

关键词：

colon cancer; mismatch repair; MSI; psychosocial; quality of life;

D O I：

10.1186/1897-4287-2-2-69

中图分类号：

学科分类号：

摘要：

Purpose: To determine which individuals with colorectal cancer (CRC) were interested in knowing the results of their tumour microsatellite instability (MSI) and immunohistochemistry (IHC) testing. We were also interested in the patients' reasons for choosing to learn their results and in the impact of those results on overall self-assessed quality of life. Patients and Methods: CRCs from 414 individuals were assayed for MSI and IHC for DNA mismatch repair gene products (MLH1, MSH2, MSH6). Individuals were invited to learn their MSI/IHC results. They randomly received either brief or extended educational materials about the testing and a pretest survey to learn reasons for their interest and to assess their pretest quality of life. Results: Of the 414 individuals, 307 (74%) chose to learn their results. There was no significant difference in interest in knowing test results according to gender, age, educational level, or family history of colon cancer. The level of detail in the information piece received by the patients did not influence their desire to know their test results. Self-assessed quality of life was not altered by receiving results and was not correlated with the test outcome. Conclusions: Individuals with colorectal cancer had a high level of interest in learning their individual MSI/IHC test results and did not seem deterred by the inherent complexity or ambiguity of this information. Regardless of test outcome, results did not significantly affect self-assessed quality of life. Further studies are needed to assess comprehension of results and behavioural changes resulting from the learning of MSI/IHC results. © The Author(s) 2004.

引用

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