Old antihypertensive agents-diuretics and β-blockers: Do we know how and in whom they lower blood pressure?

被引：2

作者：

Sica D.A. ^{[1
]}

机构：

[1] MCV Station, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298-0160

来源：

Current Hypertension Reports | 1999年 / 1卷 / 4期

关键词：

Atenolol; Plasma Renin Activity; Essential Tremor; HCTZ; Thiazide Diuretic;

D O I：

10.1007/s11906-999-0037-2

中图分类号：

学科分类号：

摘要：

Morbidity and mortality data that increasingly favor the use of diuretics and β-blockers continue to accumulate. Nonetheless, the use of these agentsóparticularly diureticsóis viewed as a dated practice. The issue of which antihypertensive drug to use will remain complex and confusing as the marketing juggernauts of the pharmaceutical industry vigorously promote drug classes such as angiotensinconverting enzyme inhibitors, angiotensin-receptor antagonists, and calcium-channel blockers. A pharmacologic middle ground will probably be reached in the form of fixed-dose combination therapy. Diuretics and b-blockers are mechanistically rational when combined with numerous other drugs; thus, the issue of which drug should be used to begin treatment will be settled by a truce, albeit an uneasy one, favoring the increased use of fixed-dose combination antihypertensive therapy. Copyright © 1999 by Current Science Inc.

引用

页码：296 / 304

页数：8

共 57 条

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