Stem cells of the liver

被引：1

作者：

Alison M. ^{[1
]}

Golding M. ^{[1
]}

Emons V. ^{[1
]}

Anilkumar T.V. ^{[1
]}

Sarraf C. ^{[1
]}

机构：

[1] Histopathology Department, Division of Investigative Science, ICSM at Hammersmith Campus, London W12 0NN, Du Cane Road

来源：

Medical Electron Microscopy | 1998年 / 31卷 / 2期

关键词：

Bile ducts; Cholangiocarcinoma; Hepatocellular carcinoma; Liver; Oval cells; Stem cells;

D O I：

10.1007/BF01557781

中图分类号：

学科分类号：

摘要：

Liver regeneration can be accomplished either by the entry of normally proliferatively quiescent, differentiated hepatocytes into the cell cycle or, if hepatocyte regeneration is impaired, by bile ductular cells that migrate centrifugally from the portal tracts before differentiating into hepatocytes. These ductal cells are called oval cells, and their emergence when hepatocyte regeneration is defective has led to the conclusion that they are the progeny of facultative stem cells. Oval cells are of great biological interest because they may be the progenitor cells of both hepatocellular carcinomas and cholangiocarcinomas; furthermore, they could be useful vehicles for ex vivo gene therapy for the correction of inborn errors of metabolism. © The Clinical Electron Microscopy Society of Japan 1998.

引用

页码：53 / 60

页数：7

共 60 条

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