Pathophysiology of ageing, longevity and age related diseases

被引:51
作者
Bürkle A. [1 ]
Caselli G. [2 ]
Franceschi C. [3 ]
Mariani E. [4 ,5 ]
Sansoni P. [6 ]
Santoni A. [7 ]
Vecchio G. [8 ]
Witkowski J.M. [9 ]
Caruso C. [10 ]
机构
[1] Department of Biology, University of Konstanz, Konstanz
[2] Department of Demographic Sciences, University La Sapienza of Rome, Rome
[3] Department of Experimental Pathology, CIG - Interdepartmental Center L. Galvani, University of Bologna, Bologna
[4] Immunology and Genetics Laboratory, Institute Codivilla-Putti, Bologna
[5] Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna
[6] Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma
[7] Department of Experimental Medicine, University La Sapienza of Rome, Rome
[8] Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples
[9] Department of Pathophysiology, Medical University of Gdansk, Gdansk
[10] Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, University of Palermo, Palermo
关键词
Natural Killer Cell; Rheumatoid Arthritis Patient; Papillary Thyroid Carcinoma; Cytolytic Activity; Human Natural Killer Cell;
D O I
10.1186/1742-4933-4-4
中图分类号
学科分类号
摘要
On April 18, 2007 an international meeting on Pathophysiology of Ageing, Longevity and Age-Related Diseases was held in Palermo, Italy. Several interesting topics on Cancer, Immunosenescence, Age-related inflammatory diseases and longevity were discussed. In this report we summarize the most important issues. However, ageing must be considered an unavoidable end point of the life history of each individual, nevertheless the increasing knowledge on ageing mechanisms, allows envisaging many different strategies to cope with, and delay it. So, a better understanding of pathophysiology of ageing and age-related disease is essential for giving everybody a reasonable chance for living a long and enjoyable final part of the life. © 2007 Bürkle et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 40 条
[1]
Caruso C., Lio D., Cavallone L., Franceschi C., Aging, longevity, inflammation, and cancer, Ann N Y Acad Sci, 1028, pp. 1-13, (2004)
[2]
Balkwill F., Mantovani A., Inflammation and cancer: Back to virchow?, Lancet, 357, pp. 539-545, (2001)
[3]
Vasto S., Candore G., Balistreri C.R., Caruso M., Colonna-Romano G., Grimaldi M.P., Listi F., Nuzzo D., Lio D., Caruso C., Inflammatory networks in ageing, age-related diseases and longevity, Mech Ageing Dev, 128, pp. 83-91, (2007)
[4]
Celetti A., Cerrato A., Merolla F., Vitagliano D., Vecchio G., Grieco M., H4(D10S170), a gene frequently rearranged with RET in papillary thyroid carcinomas: Functional characterization, Oncogene, 23, 1, pp. 109-121, (2004)
[5]
Santoro M., Melillo R.M., Carlomagno F., Vecchio G., Fusco A., Minireview: RET: Normal and abnormal functions, Endocrinology, 145, pp. 5448-5451, (2004)
[6]
Pawelec G., Barnett Y., Forsey R., Frasca D., Globerson A., McLeod J., Caruso C., Franceschi C., Fulop T., Gupta S., Mariani E., Mocchegiani E., Solana R., T cells and aging, Front Biosci, 7, (2002)
[7]
Franceschi C., Bonafe M., Centenarians as a model for healthy aging, Biochem Soc Trans, 31, pp. 457-461, (2003)
[8]
Vasto S., Caruso C., Immunity & Ageing: A new journal looking at ageing from an immunological point of view, Immun Ageing, 1, (2004)
[9]
Fagnoni F.F., Vescovini R., Passeri G., Bologna G., Pedrazzoni M., Lavagetto G., Casti A., Franceschi C., Passeri M., Sansoni P., Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging, Blood, 95, pp. 2860-2868, (2000)
[10]
Effros R.B., Pawelec G., Replicative senescence of T cells: Does the Hayflick Limit lead to immune exhaustion, Immunol Today, 18, pp. 450-454, (1997)