Lessons from placebo effects in migraine treatment

被引：41

作者：

Antonaci F. ^{[1
,2
]}

Chimento P. ^{[1
,2
]}

Diener H.-C. ^{[3
]}

Sances G. ^{[2
]}

Bono G. ^{[1
]}

机构：

[1] University Centre for Adaptive Disorders and Headache (UCADH), Section of Varese, Varese

[2] Headache Centre, IRCCS, C. Mondino Institute of Neurology Foundation, I-27100 Pavia

[3] University of Duisburg, Essen

来源：

The Journal of Headache and Pain | 2007年 / 8卷 / 1期

关键词：

Migraine; Nocebo; NSAIDs; Placebo; Triptans;

D O I：

10.1007/s10194-007-0360-4

中图分类号：

学科分类号：

摘要：

In medical research, the placebo effect is an important methodological tool. Placebo is given to participants in clinical trials, with the intention of mimicking an experimental intervention. The "nocebo" effect,on the other hand, is the phenomenon whereby a patient who believes that a treatment will cause harm actually does experience adverse effects. The placebo effect strongly influences the way the results of clinical trials are interpreted. Placebo responses vary with the choice of study design, the choice of primary outcome measure, the characteristics of the patients and the cultural setting in which the trial is conducted. In migraine trials, the placebo response is high, in terms of both efficacy and side effects. Although medical ethics committees are becoming increasingly resistant to the use of placebo in acute migraine trials, placebo nevertheless remains the pivotal comparator in trials of migraine medications. © Springer-Verlag Italia 2007.

引用

页码：63 / 66

页数：3

共 21 条

[1]

Shapiro A.K., A historic and heuristic definition of the placebo, Psychiatry, 27, pp. 52-58, (1964)

[2]

de Craen A.J.M., Placebos and placebo effects in medicine: Historical overview, J R Soc Med, 92, pp. 511-515, (1999)

[3]

Motherby G., A New Medical Dictionary or Deneral Repository of Physics, (1795)

[4]

Taber C.W., Taber's Digest of Medical Terms, (1937)

[5]

Hyland M.E., Using the placebo response in clinical practice, Clin Med, 3, pp. 347-350, (2003)

[6]

Colloca L., Benedetti F., Placebos and painkillers: Is mind as real as matter?, Nat Rev Neurosci, 6, pp. 545-552, (2005)

[7]

Benedetti F., Cholecystokinin type-A and type-B receptors and their modulation of opioid analgesia, News Physiol Sci, 12, pp. 263-268, (1997)

[8]

Benedetti F., Mayberg H.S., Wager T.D., Et al., Neurobiological mechanisms of the placebo effect, J Neurosci, 25, pp. 10390-10402, (2005)

[9]

Wager T.D., Rilling J.K., Smith E.E., Et al., Placebo-induced changes in fMRI in the anticipation and experience of pain, Science, 303, pp. 1162-1167, (2004)

[10]

Petrovic P., Kalso E., Petersson K.M., Ingvar M., Placebo and opioid analgesia - Imaging a shared neuronal network, Science, 295, pp. 1737-1740, (2002)

← 1 2 3 →