Effect of transfusion on hemoglobin variants in preterm infants

被引：10

作者：

Barkemeyer B.M. ^{[1
,2
]}

Hempe J.M. ^{[1
]}

机构：

[1] Department of Pediatrics, Louisiana State University, Medical Center, New Orleans, LA

[2] Department of Pediatrics, Louisiana State University, Medical Center, New Orleans, LA 70112

来源：

Journal of Perinatology | 2000年 / 20卷 / 6期

关键词：

D O I：

10.1038/sj.jp.7200392

中图分类号：

学科分类号：

摘要：

OBJECTIVE: To determine the effect of transfusion on hemoglobin (Hb) variants in very low birth weight infants and to correlate these changes with parameters measured in routine complete blood counts. METHODS: Hb variants were measured by capillary isoelectric focusing on 126 specimens from 25 very low birth weight infants during their hospital course. These results were compared with transfusion frequency, mean corpuscular volume (MCV), and red cell distribution width. RESULTS: Mean initial Hb F level before transfusion was 87.1 ± 5.1%, and a single 15 ml/kgpacked red blood cell transfusion decreased the mean Hb F level to 54.0 ± 4.7%. With frequent transfusions in the first month of life, there was progressive decline in Hb F content such that Hb F made up <15% of the total Hb after five transfusions. There was a linear correlation between Hb F content and MCV, with a correlation coefficient (r) of 0.77 and ap value of <0.0001. In most instances, when the MCV fell below 100 fl, the Hb F content was <50%; when the MCV fell below 95 fl, the Hb F content was <25%. There was a nonlinear correlation between Hb F content and red cell distribution width. CONCLUSION: Transfusion in very low birth weight infants results in a rapid transition from Hb F to Hb A predominance. This transition is marked by a reduction in MCV that allows for prediction of the Hb F content.

引用

页码：355 / 358

页数：3

共 13 条

[1]

Shannon K.M., Keith J.F., Mentzer W.C., Et al., Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusion in very low birth-weight preterm infants, Pediatrics, 95, pp. 1-8, (1995)

[2]

Strauss R.G., Transfusion therapy in neonates, Am J Dis Child, 145, pp. 904-911, (1991)

[3]

Bard H., Postnatal fetal and adult hemoglobin synthesis in early preterm newborn infants, J Clin Invest, 52, pp. 1789-1795, (1973)

[4]

Bard H., The postnatal decline of hemoglobin f synthesis in normal full-term infants, J Clin Invest, 55, pp. 395-398, (1975)

[5]

Hempe J.M., Craver R.D., Quantification of hemoglobin variants by capillary isoelectric focusing, Clin Chem, 40, pp. 2288-2295, (1994)

[6]

Hempe J.M., Granger J.G., Craver R.D., Capillary isoelectric focusing of hemoglobin variants in the pediatric clinical laboratory, Electrophoresis, 18, pp. 1785-1795, (1997)

[7]

Bard H., Fouron J.C., Gagnon C., Gagnon J., Hypoxemia and increased fetal hemoglobin synthesis, J Pediatr, 124, pp. 941-943, (1994)

[8]

Bard H., Prosmanne J., Elevated level of fetal hemoglobin synthesis in infants with bronchopulmonary dysplasia, Pediatrics, 86, pp. 193-196, (1990)

[9]

Bard H., Lachance C., Widness J.A., Gagnon C., The reactivation of fetal hemoglobin synthesis during anemia of prematurity, Pediatr Res, 36, pp. 253-256, (1994)

[10]

Brown M.S., Phipps R.H., Dallman P.R., Postnatal changes in fetal hemoglobin, oxygen affinity, and 2,3-diphosphoglerate in previously transfused preterm infants, Biol Neonate, 48, pp. 70-76, (1985)

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