Obstructive sleep apnea and hypertension

被引：47

作者：

Narkiewicz K. ^{[1
]}

Wolf J. ^{[1
]}

Lopez-Jimenez F. ^{[1
]}

Somers V.K. ^{[1
]}

机构：

[1] Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdansk, 80-952 Gdansk

来源：

Current Cardiology Reports | 2005年 / 7卷 / 6期

关键词：

Obstructive Sleep Apnea; Sleep Apnea; Continuous Positive Airway Pressure; Obstructive Sleep Apnea Syndrome; Respir Crit;

D O I：

10.1007/s11886-005-0061-z

中图分类号：

学科分类号：

摘要：

There is growing evidence of a causal relationship between obstructive sleep apnea (OSA) and hypertension. Untreated OSA may have direct and deleterious effects on cardiovascular function and structure through several mechanisms, including sympathetic activation, oxidative stress, inflammation, and endothelial dysfunction. OSA may contribute to or augment elevated blood pressure levels in a large proportion of the hypertensive patient population. It is important to consider OSA in the differential diagnosis of hypertensive patients who are obese. OSA should be especially considered in those hypertensive patients who respond poorly to combination therapy with antihypertensive medications. Copyright © 2005 by Current Science Inc.

引用

页码：435 / 440

页数：5

共 50 条

[1]

Phillipson E.A., Sleep apnea - A major public health problem, N. Engl. J. Med., 328, pp. 1271-1273, (1993)

[2]

Bearpark H., Elliott L., Grunstein R., Et al., Snoring and sleep apnea. A population study in Australian men, Am. J. Respir. Crit. Care Med., 151, pp. 1459-1465, (1995)

[3]

Vgontzas A.N., Tan T.L., Bixler E.O., Et al., Sleep apnea and sleep disruption in obese patients, Arch. Intern. Med., 154, pp. 1705-1711, (1994)

[4]

Strollo P.J., Rogers R.M., Obstructive sleep apnea, N. Engl. J. Med., 334, pp. 99-104, (1996)

[5]

Brooks D., Horner R.L., Kozar L.F., Et al., Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model, J. Clin. Invest., 99, pp. 106-109, (1997)

[6]

Bixler E.O., Vgontzas A.N., Lin H.M., Et al., Association of hypertension and sleep-disordered breathing, Arch. of Intern. Med., 160, pp. 2289-2295, (2000)

[7]

Young T., Peppard P., Palta M., Et al., Population-based study of sleep-disordered breathing as a risk factor for hypertension, Arch. Intern. Med., 157, pp. 1746-1752, (1997)

[8]

Peppard P.E., Young T., Palta M., Skatrud J., Prospective study of the association between sleep-disordered breathing and hypertension, N. Engl. J. Med., 342, pp. 1378-1784, (2000)

[9]

Nieto F.J., Young T.B., Bonnie K.L., Et al., Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study, JAMA, 283, pp. 1829-1836, (2000)

[10]

Haas D.C., Foster G.L., Nieto F.J., Et al., Age-dependent associations between sleep-disordered breathing and hypertension: Importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study, Circulation, 111, pp. 614-621, (2005)

← 1 2 3 4 5 →