Transcranial direct current stimulation for major depression: A general system for quantifying transcranial electrotherapy dosage

被引：46

作者：

Bikson M. ^{[1
]}

Bulow P. ^{[1
]}

Stiller J.W. ^{[1
]}

Datta A. ^{[1
]}

Battaglia F. ^{[1
]}

Karnup S.V. ^{[1
]}

Postolache T.T. ^{[1
]}

机构：

[1] Mood and Anxiety Program, University of Maryland School of Medicine, Baltimore, MD 21201

来源：

Current Treatment Options in Neurology | 2008年 / 10卷 / 5期

关键词：

Transcranial Magnetic Stimulation; Deep Brain Stimulation; Vagus Nerve Stimulation; Main Drug Interaction; Dorsolateral Prefrontal Cortex;

D O I：

10.1007/s11940-008-0040-y

中图分类号：

学科分类号：

摘要：

There has been a recent resurgence of interest in therapeutic modalities using transcranial weak electrical stimulation through scalp electrodes, such as transcranial direct current stimulation (tDCS), as a means of experimentally modifying and studying brain function and possibly treating psychiatric conditions. A range of electrotherapy paradigms have been investigated, but no consistent method has been indicated for reporting reproducible stimulation "dosage." Anecdotal reports, case studies, and limited clinical trials with small numbers suggest that tDCS may be effective in treating some patients with depression, but methods for selecting the optimal stimulation parameters ("dosage") are not clear, and there is no conclusive indication that tDCS is an effective treatment for depression. Larger, controlled studies are necessary to determine its safety and efficacy in a clinical setting. If tDCS can be established as an effective treatment for depression, it would represent a particularly attractive electrotherapy option, as it is a relatively benign and affordable treatment modality. An accurate system for describing reproducible treatment parameters is essential so that further studies can yield evidence-based guidelines for the clinical use of transcranial current stimulation. Development of appropriate parameters requires a biophysical understanding of how electrotherapy affects brain function and should include different paradigms for different clinical applications. As with any dosage guidelines, such a system does not supersede physician judgment on safety. © Springer Science+Business Media, LLC 2008.

引用

页码：377 / 385

页数：8

共 29 条

[1]

Lisanby S.H., Maddox J.H., Prudic J., Et al., The effects of electroconvulsive therapy on memory of autobiographical and public events, Arch Gen Psychiatry, 57, pp. 581-590, (2000)

[2]

Sackeim H.A., Prudic J., Devanand D.P., Et al., A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities, Arch Gen Psychiatry, 57, pp. 425-434, (2000)

[3]

Lisanby S.H., Electroconvulsive therapy for depression, N Engl J Med, 357, pp. 1939-1945, (2007)

[4]

Aouizerate B., Cuny E., Martin-Guehl C., Et al., Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression, J Neurosurg, 101, pp. 682-686, (2004)

[5]

Greenberg B.D., Malone D.A., Friehs G.M., Et al., Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder, Neuropsychopharmacology, 31, pp. 2384-2393, (2006)

[6]

Rush A.J., Marangell L.B., Sackeim H.A., Et al., Vagus nerve stimulation for treatment-resistant depression: A randomized, controlled acute phase trial, Biol Psychiatry, 58, pp. 347-354, (2005)

[7]

O'Reardon J.P., Solvason H.B., Janicak P.G., Et al., Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: A multisite randomized controlled trial, Biol Psychiatry, 62, pp. 1208-1216, (2007)

[8]

Fregni F., Boggio P., Nitsche M., Et al., Treatment of major depression with transcranial direct current stimulation, Bipolar Disord, 8, pp. 203-204, (2006)

[9]

Boggio P.S., Rigonatti S.P., Ribeiro R.B., Et al., A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression, Int J Neuropsychopharmacol, 11, pp. 249-254, (2008)

[10]

Bikson M., Radman T., Datta A., Rational modulation of neuronal processing with applied electric fields, Conf Proc IEEE Eng Med Biol Soc, 1, pp. 1616-1619, (2006)

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