New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma

被引：128

作者：

Abraham D.J. ^{[1
]}

Eckes B. ^{[1
]}

Rajkumar V. ^{[1
]}

Krieg T. ^{[1
]}

机构：

[1] Department of Medicine, Royal Free and University College Medical School, University College London (Hampstead Campus), London NW3 2PF, Rowland Hill Street

来源：

Current Rheumatology Reports | 2007年 / 9卷 / 2期

关键词：

Scleroderma; Systemic Sclerosis; Connective Tissue Growth Factor; Cartilage Oligomeric Matrix Protein; Mesenchymal Cell Population;

D O I：

10.1007/s11926-007-0008-z

中图分类号：

学科分类号：

摘要：

The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wound healing and tissue repair, fibroblasts provide proinflammatory signals and synthesize interstitial collagens, fibronectins, and other matrix components to repair the damaged tissue. Fibroblasts can differentiate into the myofibroblast, a specialized contractile cell type responsible for wound closure, tissue contraction, and scarring. This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：136 / 143

页数：7

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