Current usefulness of procaine penicillin in the treatment of pneumococcal pneumonia

被引：9

作者：

Cabellos C. ^{[1
]}

Ariza J. ^{[1
]}

Barreiro B. ^{[2
]}

Tubau F. ^{[3
]}

Liñares J. ^{[3
]}

Pallarés R. ^{[1
]}

Manresa F. ^{[2
]}

Gudiol F. ^{[1
]}

机构：

[1] Service of Infectious Diseases, Ciutat Sanit. i Univ. de Bellvitge, University of Barcelona, C/Feixa Llarga s/n

[2] Service of Pulmonary Diseases, Ciutat Sanit. i Univ. de Bellvitge, University of Barcelona, C/Feixa Llarga s/n

[3] Service of Microbiology, Ciutat Sanit. i Univ. de Bellvitge, University of Barcelona, C/Feixa Llarga s/n

来源：

European Journal of Clinical Microbiology and Infectious Diseases | 1998年 / 17卷 / 4期

关键词：

Internal Medicine; Pneumonia; Serum Level; Penicillin; Streptococcus Pneumoniae;

D O I：

10.1007/BF01699983

中图分类号：

学科分类号：

摘要：

The aim of this study was to determine whether procaine penicillin could be used in the treatment of suspected pneumococcal pneumonia of mild to moderate severity in an area with a high prevalence of penicillin resistance. Forty-nine patients were treated with 1.2 · 106 U of i.m. procaine penicillin every 12 h. By intent-to-treat analysis, 40 of 49 patients were cured and no patient died. Streptococcus pneumoniae could be demonstrated in 17 patients; 5 of 17 isolates were resistant to penicillin (MICs 0.25-4 μg/ml). Fifteen of 17 patients were cured with procaine penicillin, one presented allergy, and one was a therapeutic failure. Mean penicillin serum levels were 2.39 ± 1.16 μg/ml (peak) and 0.61 ± 0.38 μg/ml (trough). The results suggest that procaine penicillin map still be useful in the empirical therapy of suspected pneumococcal pneumonia.

引用

页码：265 / 268

页数：3

共 15 条

[1] Appelbaum, P.C., Bhamjee, A., Scragg, J.N., Hallett, A.F., Bowen, A.J., Cooper, C.R., Streptococcus pneumoniae resistant to penicillin and chloramphenicol (1977) Lancet, 2, pp. 995-997
[2] Fenoll, A., Martin-Bourgon, C., Muñoz, R., Vicioso, D., Casal, J., Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing syste mic infection in Spain, 1979-1989 (1991) Reviews of Infectious Diseases, 13, pp. 56-60
[3] Liñares, J., Pallares, R., Alonso, T., Perez, J.L., Ayats, J., Gudiol, F., Viladrich, P.F., Martin, R., Trends in antimicrobial resistance of clinical isolates of Streptococcus pneumoniae in Bellvitge Hospital, Barcelona, Spain 1979-1990 (1992) Clinical Infectious Diseases, 15, pp. 99-105
[4] Appelbaum, P.C., Antimicrobial resistance in Streptococcus pneumoniae: An overview (1992) Clinical Infectious Diseases, 15, pp. 77-83
[5] Friedland, I.R., McCracken Jr., G.H., Management of infections caused by antibiotic-resistant Streptococcus pneumoniae (1994) New England Journal of Medicine, 331, pp. 377-382
[6] Pallares, R., Gudiol, F., Liñares, J., Ariza, J., Rufi, G., Murgui, L., Dorca, J., Ariza, J., Risk factors and response to antibiotic therapy in adults with bacteremic pneumonia caused by penicillin-resistant pneumococci (1987) New England Journal of Medicine, 317, pp. 18-22
[7] Musher, D.M., Streptococcus pneumoniae (1995) Principles and Practice of Infectious Diseases, pp. 1811-1826. , Mandell GL, Bennett JE, Dolin R (eds): Churchill Livingstone, New York
[8] Dorea, J., Manresa, F., Esteban, L.L., Barreiro, B., Prats, E., Ariza, J., Verdaguer, R., Gudiol, F., Efficacy, safety and therapeutic relevance of transthoracic aspiration with ultrathin needle in non-ventilated nosocomial pneumonia (1995) American Journal of Respiratory and Critical Care Medicine, 151, pp. 1491-1496
[9] Chapin-Robertson, K., Edberg, S.C., Measurements of antibiotics in human body fluids: Techniques and significance (1991) Antibiotics in Laboratory Medicine, pp. 295-366. , Lorian V (ed): Williams &. Wilkins, Baltimore
[10] Griffin, J., Serum inhibitory and bactericidal titers (1992) Clinical Microbiology Procedures Handbook, pp. 1-18. , Isenberg HD (ed.): American Society for Microbiology, Washington DC

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