Growing evidence for diabetes susceptibility genes from gerome scan data

被引：82

作者：

Mark I. McCarthy

机构：

[1] Oxford Ctr. for Diabetes Endocrinol., Wellcome Trust Ctr. for Human Genet., Oxford OX3 7BN, Roosevelt Drive

来源：

Current Diabetes Reports | 2003年 / 3卷 / 2期

关键词：

Susceptibility Locus; Genome Scan; Diabetes Susceptibility; Diabetes Susceptibility Gene; Multifactorial Trait;

D O I：

10.1007/s11892-003-0040-y

中图分类号：

学科分类号：

摘要：

Genome-wide scans for linkage have provided one of the dominant approaches adopted by researchers in their efforts to identify genes responsible for the inherited component of type 2 diabetes susceptibility. Around 20 genome scans have now been completed, in a wide variety of populations. Integration of data from these diverse scans has proven far from trivial, but the contours of genome-wide linkage topography are steadily emerging from the fog of data. Identification of the calpain-10 gene as the probable basis for the chromosome 2q linkage seen in Mexican Americans has provided validation of this positional cloning approach. This report provides an update on recent type 2 diabetes genome scan data, focusing on several chromosomal regions where the evidence for linkage has considerably strengthened in the past year. The current and future value of genome-wide linkage information in the search for type 2 diabetes susceptibility effects is also discussed. Copyright © 2003 by Current Science Inc.

引用

页码：159 / 167

页数：8

共 50 条

[1]

Zimmet P., Alberti K.G., Shaw J., Global and societal implications of the diabetes epidemic, Nature, 414, pp. 782-787, (2001)

[2]

Lander E.S., Schork N.J., Genetic dissection of complex traits, Science, 265, pp. 2637-2648, (1994)

[3]

Hirschhorn J.N., Lohmueller K., Byrne E., Hirschhorn K., A comprehensive review of genetic association studies, Genet. Med., 4, pp. 45-61, (2002)

[4]

Cardon L.R., Bell J.I., Association study designs for complex disease, Nat. Rev Genet., 2, pp. 91-99, (2001)

[5]

Wright A.F., Hastie N.D., Complex genetic diseases: Controversy over the Croesus code, Genome Biol., 2, (2001)

[6]

Owen K., Hattersley A.T., Maturity-onset diabetes of the young: From clinical description to molecular genetic characterization, Best Pract. Res. Clin. Endocrinol. Metab., 15, pp. 309-323, (2001)

[7]

Hanis C.L., Boerwinkle E., Chakraborty R., Et al., A genomewide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2, Nat. Genet., 13, pp. 161-171, (1996)

[8]

Mahtani M.M., Widen E., Lehto M., Et al., Mapping of a gene for NIDDM associated with an insulin secretion defect by a genome scan in Finnish families, Nat. Genet., 14, pp. 90-95, (1996)

[9]

Hanson R.L., Ehm M.G., Pettitt D.J., Et al., An autosomal genomic scan for loci linked to type 2 diabetes mellitus and body-mass index in Pima Indians, Am. J. Hum. Genet., 63, pp. 1124-1132, (1998)

[10]

Pratley R.E., Thompson D.B., Prochazka M., Et al., An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians, J. Clin. Invest., 101, pp. 1757-1764, (1998)

← 1 2 3 4 5 →