Serum copper in Alzheimer's disease and vascular dementia

被引：28

作者：

Agarwal R. ^{[1
]}

Kushwaha S.S. ^{[2
]}

Tripathi C.B. ^{[3
]}

Singh N. ^{[1
]}

Chhillar N. ^{[1
]}

机构：

[1] Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, Delhi

[2] Department of Neurology, Institute of Human Behaviour and Allied Sciences, Delhi

[3] Department of Biostatistics, Institute of Human Behaviour and Allied Sciences, Delhi

来源：

Indian Journal of Clinical Biochemistry | 2008年 / 23卷 / 4期

基金：

英国科研创新办公室;

关键词：

Alzheimer's disease; Ceruloplasmin; Copper; Neurodegeneration; Oxidative stress; Vascular dementia;

D O I：

10.1007/s12291-008-0081-8

中图分类号：

学科分类号：

摘要：

Alzheimer's disease is the most common form of dementia in the elderly and it's prevalence is rapidly rising. Oxidative stress plays important role in the pathophysiology of Alzheimer's disease. Metals like copper, iron derived through diet can act as pro-oxidant under oxidative stress. In the present study, serum copper levels were evaluated in 50 patients with Alzheimer's disease, 24 patients with Vascular Dementia and 30 controls. All the groups were also investigated for serum ceruloplsmin levels. The mean copper levels in Alzheimer's disease and Vascular Dementia were significantly raised compared to controls. An attempt has been made to study the relationship of serum copper with ceruloplasmin. Our study found weak correlation between copper and ceruloplasmin levels in Alzheimer's disease and Vascular Dementia.

引用

页码：369 / 374

页数：5

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