Sevoflurane postconditioning provides neuroprotection against brain hypoxia–ischemia in neonatal rats

被引：18

作者：

Xiaoyan Ren

Zhi Wang

Hong Ma

Zhiyi Zuo

机构：

[1] The First Hospital of China Medical University,Department of Anesthesiology

[2] University of Virginia Health System,Department of Anesthesiology

[3] Sun Yat-Sen Memorial Hospital,Department of Anesthesiology

[4] Sun Yat-Sen University,undefined

来源：

Neurological Sciences | 2014年 / 35卷

关键词：

Brain hypoxia–ischemia; Neonates; Postconditioning; Sevoflurane;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Application of volatile anesthetics after brain ischemia provides neuroprotection in adult animals (anesthetic postconditioning). We tested whether postconditioning with sevoflurane, the most commonly used general anesthetic in pediatric anesthesia, reduced neonatal brain injury in rats. Seven-day-old Sprague–Dawley rats were subjected to brain hypoxia–ischemia (HI). They were postconditioned with sevoflurane in the presence or absence of 5-hydroxydecanoic acid, a mitochondrial KATP channel inhibitor. Sevoflurane postconditioning dose-dependently reduced brain tissue loss observed 7 days after brain HI. This effect was induced by clinically relevant concentrations and abolished by 5-hydroxydecanoic acid. These results suggest that sevoflurane postconditioning protects neonatal brain against brain HI via mitochondrial KATP channels.

引用

页码：1401 / 1404

页数：3

共 101 条

[1]

Ferriero DM(2004)Neonatal brain injury N Engl J Med 351 1985-1995

[2]

Lynch JK(2001)Epidemiology of perinatal stroke Curr Opin Pediatr 13 499-505

[3]

Nelson KB(1988)Outcome of neonatal strokes Am J Dis Child 142 1086-1088

[4]

Sran SK(2000)Cerebral infarction in the term new-born: clinical presentation and long-term outcome J Pediatr 137 351-355

[5]

Baumann RJ(2010)Towards improved animal models of neonatal white matter injury associated with cerebral palsy Dis Models Mech 3 678-688

[6]

Sreenan C(2008)Postconditioning with isoflurane reduced ischemia-induced brain injury in rats Anesthesiology 108 1055-1062

[7]

Bhargave R(2010)Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway Stroke 41 1521-1527

[8]

Robertson CM(1999)Anaesthesia BMJ 319 557-560

[9]

Silbereis JC(2005)The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo Anesth Analg 101 1252-1260

[10]

Huang EJ(2007)Isoflurane preconditioning improves long-term neurologic outcome after hypoxic-ischemic brain injury in neonatal rats Anesthesiology 107 963-970

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