Sound waves and antineoplastic drugs: The possibility of an enhanced combined anticancer therapy

被引:41
作者
Loreto B Feril
Takashi Kondo
Shin-ichiro Umemura
Katsuro Tachibana
Angelo H Manalo
Peter Riesz
机构
[1] Department of Radiological Sciences Toyama Medical and Pharmaceutical University,College of Medicine Mindanao State University
[2] Hitachi,Radiation Biology Branch National Cancer Institute
[3] Ltd Central Research Laboratory,undefined
[4] First Department of Anatomy Fukuoka University School of Medicine,undefined
[5] MSU-IIT,undefined
[6] NIH,undefined
关键词
anti-cancer agent; combined anticancer therapy; shock wave; ultrasound;
D O I
10.1007/BF02480848
中图分类号
学科分类号
摘要
Kremkau wrote a historical review of the use of ultrasound in cancer therapy in 1979(1) In 1990, Kondo and Kano published a Japanese review of the implications of the thermal and nonthermal effects of ultrasound in the treatment of cancer2). Again in 2000, Kondo et al reviewed the therapeutic applications of ultrasound and shock wave, emphasizing their thermal and cavitational effects3). Here we focus on the effects of ultrasound or shock waves in combination with anticancer agents, emphasizing their mechanisms of action and interaction. Most of the studies cited here reported promising results. Although the extent of the augmented combined effects in vivo is limited, synergism is the rule in vitro. In addition to the thermal effect of ultrasound, cavitational effects undoubtedly played a major role in both ultrasound and, more prominently, in shock wave therapy. Although the mechanism of the nonthermal noncavitational effects on biological processes is obscure, several factors, including temperature and the occurrence of cavitation and inertial cavitation, probably coexist and blend with these other effects. Magnification of anticancer activity results mainly from increased localization of drugs or other agents in vivo and increased intracellular permeabilisation both in vivo and in vitro. On the other hand, sublethal damage caused by ultrasound or shock waves may render cells more susceptible, to the effects of the agents, and both may act together, further amplifying these effects. We thus conclude that proper combination of an appropriate agent and ultrasound or shock wave should help improve cancer therapy by minimizing the side effects of drugs by lowering the effective dose and reducing the systemic concentration while increasing the efficiency of the therapy as a whole. Future studies should reveal specific conditions in this combined therapy that will lead to optimal outcome.
引用
收藏
页码:173 / 187
页数:14
相关论文
共 324 条
[1]  
Kremkau FW(1979)Cancer therapy with ultrasound: a historical review J Clin Ultrasound 7 287-300
[2]  
Kondo T(1990)The possibility of ultrasonic cancer therapy and some of the difficulties: implications of the thermal and nonthermal effects Jpn J Hyperthermic Oncol 6 1-18
[3]  
Kano E(2000)Novel therapeutic application of ultrasound: utilization of thermal and cavitational effects Jpn J Hyperthermic Oncol 16 203-216
[4]  
Kondo T(1979)Cancer therapy with ultrasound: a historical review J Clin Ultrasound 7 287-300
[5]  
Umemura S(1990)Histological changes in rat liver tumors treated with high-intensity focused ultrasound Ultrasound Med Biol 19 67-74
[6]  
Tanabe K(1990)Sonochemistry Science 247 1439-1445
[7]  
Hill CR(1992)Free radical formation induced by ultrasound and its biological implications Free Radic Biol Med 13 247-270
[8]  
Kremkau FW(1989)Ultrasound enhanced drug toxicity on Chinese hamster ovary cells in vitro Cancer Res 49 5931-5934
[9]  
Chen L(1990)The effect of ultrasound on the cytotoxicity of adriamycin Br J Radiol 63 542-546
[10]  
Rivens I(1996)In vitro action of continuous-wave ultrasound combined with adriamycin, x-rays or hyperthermia Radiat Res 145 98-101