Leukemia vaccines.

被引：7

作者：

Kochenderfer J.N. ^{[1
]}

Molldrem J.J. ^{[1
]}

机构：

[1] Division of Medicine and Section of Transplant Immunology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, TX

来源：

Current Oncology Reports | 2001年 / 3卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Human Leukocyte Antigen; Acute Myelogenous Leukemia; Human Leukocyte Antigen Class; Donor Lymphocyte Infusion; Human Leukocyte Antigen Molecule;

D O I：

10.1007/s11912-001-0050-3

中图分类号：

学科分类号：

摘要：

Leukemia is susceptible to immune-mediated therapies such as allogeneic stem-cell transplantation, donor lymphocyte infusion, and interferon. The clinical effectiveness of these immune-based modalities has encouraged interest in vaccine therapies for leukemia. Substantial progress has recently been made in basic immunology, allowing scientifically based vaccination strategies to be developed. The discovery of leukemia- specific and leukemia-associated antigens will allow antigen-specific therapeutic strategies to be developed. Vaccination with genetically modified leukemia cells and the use of dendritic cells in various vaccination approaches are all promising avenues of study for development of effective leukemia vaccines.

引用

页码：193 / 200

页数：7

共 142 条

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