Estimating the role of casual contact from the community in transmission of Bordetella pertussis to young infants

被引：45

作者：

Wendelboe A.M. ^{[1
]}

Hudgens M.G. ^{[2
]}

Poole C. ^{[1
]}

Van Rie A. ^{[1
]}

机构：

[1] Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC

[2] Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC

来源：

Emerging Themes in Epidemiology | / 4卷 / 1期

关键词：

Pertussis; Multiple Imputation; Index Case; Percent Confidence Interval; Complete Case Analysis;

D O I：

10.1186/1742-7622-4-15

中图分类号：

学科分类号：

摘要：

The proportion of infant pertussis cases due to transmission from casual contact in the community has not been estimated since before the introduction of pertussis vaccines in the 1950s. This study aimed to estimate the proportion of pertussis transmission due to casual contact using demographic and clinical data from a study of 95 infant pertussis cases and their close contacts enrolled at 14 hospitals in France, Germany, Canada, and the U.S. between February 2003 and September 2004. A complete case analysis was conducted as well as multiple imputation (MI) to account for missing data for participants and close contacts who did not participate. By considering all possible close contacts, the MI analysis estimated 66% of source cases were close contacts, implying the minimum attributable proportion of infant cases due to transmission from casual contact with community members was 34% (95% CI = 24%, 44%). Estimates from the complete case analysis were comparable but less precise. Results were sensitive to changes in the operational definition of a source case, which broadened the range of MI point estimates of transmission from casual community contact to 20%-47%. We conclude that casual contact appears to be responsible for a substantial proportion of pertussis transmission to young infants. Medical subject headings (MeSH): multiple imputation, pertussis, transmission, casual contact, sensitivity analysis, missing data, community. © 2007 Wendelboe et al; licensee BioMed Central Ltd.

引用

共 45 条

[1]

Broder K.R., Cortese M.M., Iskander J.K., Kretsinger K., Slade B.A., Brown K.H., Mijalski C.M., Tiwari T., Weston E.J., Cohn A.C., Srivastava P.U., Moran J.S.J.S., Schwartz B., Murphy T.V., Preventing tetanus, diphtheria, and pertussis among adolescents: Use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines recommendations of the Advisory Committee on Immunization Practices (ACIP), MMWR Recomm Rep, 55, RR-3, pp. 1-34, (2006)

[2]

Celentano L.P., Massari M., Paramatti D., Salmaso S., Tozzi A.E., Resurgence of pertussis in Europe, Pediatr Infect Dis J, 24, pp. 761-765, (2005)

[3]

Edwards K.M., Overview of pertussis: Focus on epidemiology, sources of infection, and long term protection after infant vaccination, Pediatr Infect Dis J, 24, pp. 104-8, (2005)

[4]

Cdc, National, State, and Urban Area Vaccination Coverage among Children Aged 19 - 35 Months - - United States, 2004, MMWR, 54, pp. 717-721, (2005)

[5]

Grimprel E., Baron S., Levy-Bruhl D., Garnier J.M., N'Jamkepo E., Guiso N., Begue P., Influence of vaccination coverage on pertussis transmission in France, Lancet, 354, pp. 1699-1700, (1999)

[6]

Bentsi-Enchill A.D., Halperin S.A., Scott J., MacIsaac K., Duclos P., Estimates of the effectiveness of a whole-cell pertussis vaccine from an outbreak in an immunized population, Vaccine, 15, pp. 301-306, (1997)

[7]

Cdc, Vaccination Coverage among Children Entering School - - United States, 2003 - 04 School Year, MMWR Morb Mortal Wkly Rep, 53, pp. 1041-1044, (2004)

[8]

Anderson R.M., May R.M., Infectious Diseases of Humans, (1991)

[9]

Kendrick P., Elderling G., A study in active immunisation against pertussis, American Journal of Hygeine, 29, pp. 133-153, (1939)

[10]

Broder K.R., Cortese M.M., Iskander J.K., Kretsinger K., Slade B.A., Brown K.H., Mijalski C.M., Tiwari T., Weston E.J., Cohn A.C., Srivastava P.U., Moran J.S., Schwartz B., Murphy T.V., Preventing tetanus, diphtheria, and pertussis among adolescents: Use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Early Release, MMWR Morb Mortal Wkly Rep, 55, pp. 1-43, (2006)

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