Interleukin-4 and breast cancer

被引：42

作者：

Nagai S. ^{[1
]}

Toi M. ^{[1
]}

机构：

[1] Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo

来源：

Breast Cancer | 2000年 / 7卷 / 3期

关键词：

Breast cancer; IL-4;

D O I：

10.1007/BF02967457

中图分类号：

学科分类号：

摘要：

IL-4 is a pleiotropic cytokine produced by T lymphocytes which acts on various cells of such as T and B lymphocytes, monocytes, fibroblast, endothelial cells, macrophages and some others. IL-4 was originary described as a B cell growth factor, and now known to provide potent anti-tumor activity against various tumors, including breast cancer. IL-4 can induce apoptosis in cultured breast cancer cells. In addtion, it has been clarified that IL-4 plays an important role in the regulation of estrogen synthesis enzymes including 17β-HSD and 3β-HSD. These findings imply that IL-4 is a key enzyme not only for Th2 type immune reactions but also for tumor cell growth itself in human breast cancer.

引用

页码：181 / 186

页数：5

共 59 条

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