B lymphocyte stimulator protein levels in systemic lupus erythematosus and other diseases.

被引：26

作者：

Stohl W. ^{[1
]}

机构：

[1] University of Southern California Keck School of Medicine, Division of Rheumatology, 2011 Zonal Avenue HMR 711, Los Angeles, 90033, CA

来源：

Current Rheumatology Reports | 2002年 / 4卷 / 4期

基金：

美国国家卫生研究院;

关键词：

Systemic Lupus Erythematosus; Lymphocyte Stimulator; Tumor Necrosis Factor Family; Soluble Fusion Protein; Tumor Necrosis Factor Ligand;

D O I：

10.1007/s11926-002-0044-7

中图分类号：

学科分类号：

摘要：

The size of the known members of the tumor necrosis factor ligand and receptor superfamilies has burgeoned in the past few years. Among the novel tumor necrosis factor ligand and receptor superfamily members recently described is B lymphocyte stimulator (BLyS; Human Genome Sciences, Rockville, MD) protein. By virtue of its ability to promote B-cell survival, expansion, and differentiation, it likely plays an important contributory role in systemic lupus erythematosus pathogenesis and propagation. In addition, it may play a similar role in other systemic immune-based rheumatic diseases, and becomes a legitimate candidate target for antagonist biologic agents.

引用

页码：345 / 350

页数：5

共 143 条

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