Heparin-induced thrombocytopenia: An update

被引：89

作者：

Franchini M. ^{[1
,2
]}

机构：

[1] Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona

[2] Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, 37134 Verona

来源：

Thrombosis Journal | / 3卷 / 1期

关键词：

Heparin; Platelets; Thrombosis;

D O I：

10.1186/1477-9560-3-14

中图分类号：

学科分类号：

摘要：

Heparin-induced thrombocytopenia (HIT) is the most important and most frequent drug-induced, immune-mediated type of thrombocytopenia. It is associated with significant morbidity and mortality if unrecognized. In this review, we briefly discuss the main features of heparin-induced thrombocytopenia, particularly analyzing the most recent advances in the pathophysiology, diagnosis and treatment of this syndrome. © 2005 Franchini; licensee BioMed Central Ltd.

引用

页数：19

共 53 条

[1]

Chong B.H., Heparin-induced thrombocytopenia, J. Thromb. Haemost., 1, pp. 1471-1478, (2003)

[2]

Jang I.-K., Hursting H.J., When heparins promote thrombosis. Review of heparin-induced thrombocytopenia, Circulation, 111, pp. 2671-2683, (2005)

[3]

Warkentin T.E., Heparin-induced thrombocytopenia: Pathogenesis and management, Br. J. Haematol., 121, pp. 535-555, (2003)

[4]

Warkentin T.E., Heparin-induced thrombocytopenia. Diagnosis and management, Circulation, 110, (2004)

[5]

Cines D.B., Bussel J.B., McMillan R.B., Zehnder J.L., Congenital and acquired thrombocytopenia, Hematology (Am. Soc. Hematol. Educ. Program), pp. 390-406, (2004)

[6]

Warkentin T.E., Greinacher A., Heparin-induced thrombocytopenia: Recognition, treatment, and prevention: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy, Chest, 126, 3 SUPPL., (2004)

[7]

Strauss R., Wehler M., Mehler K., Kreutzer D., Koebnick C., Hahn E.G., Thrombocytopenia in patients in the medical intensive care unit: Bleeding prevalence, transfusion requirements, and outcome, Crit. Care Med., 30, pp. 1765-1771, (2002)

[8]

Warkentin T.E., An overview of the heparin-induced thrombocytopenia syndrome, Semin. Thromb. Hemost., 30, pp. 273-283, (2004)

[9]

Rice L., Heparin-induced thrombocytopenia: Myths and misconceptions (that will cause trouble for you and your patient), Arch. Intern. Med., 164, pp. 1961-1964, (2004)

[10]

Warkentin T.E., Levine M.N., Hirsh J., Et al., Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin, N. Engl. J. Med., 332, pp. 1330-1335, (1995)

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