Detection of Candida mannoproteinemia in patients with neutropenic enterocolitis

被引：13

作者：

Girmenia C. ^{[1
]}

Micozzi A. ^{[1
]}

Cartoni C. ^{[1
]}

De Bernardis F. ^{[2
]}

Cassone A. ^{[2
]}

Martino P. ^{[1
]}

机构：

[1] Dipto. di Biotecnologie Cellulari, University La Sapienza, Via Benevento 6

[2] Dept. of Bacteriol./Med. Mycology, Istituto Superiore di Sanita', Via Regina Elena

来源：

European Journal of Clinical Microbiology and Infectious Diseases | 1999年 / 18卷 / 1期

关键词：

Serum Sample; Diagnostic Tool; Fluconazole; Hematologic Malignancy; Antifungal Agent;

D O I：

10.1007/s100960050226

中图分类号：

学科分类号：

摘要：

To assess the role of Candida spp. in the etiology of neutropenic enterocolitis complicating aggressive cytotoxic chemotherapy, a dot immunobinding assay for an immunodominant Candida mannoprotein antigen was employed in 20 patients with hematologic malignancies. Candida antigen was detected in at least one serum sample from 12 (60%) patients. Eleven (92%) patients were cured when an antifungal agent was added to the antibacterial treatment. In eight patients a selective anticandidal therapy with fluconazole was administered on the basis of positive Candida mannoproteinemia, and treatment was successful in all cases but one. Detection of Candida mannoproteinemia seems to be a useful diagnostic tool in patients with neutropenic enterocolitis and represents an additional tool for selecting a less empiric, low toxic antifungal treatment with fluconazole.

引用

页码：55 / 58

页数：3

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