Epibatidine: Impact on nicotinic receptor research

被引：20

作者：

Małgorzata Dukat ^{[1
]}

Richard A. Glennon ^{[1
]}

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA

[2] Department of Medicinal Chemistry, Virginia Commonwealth University, Box 980540, Richmond

来源：

Cellular and Molecular Neurobiology | 2003年 / 23卷 / 3期

关键词：

Cholinergic receptors; Epibatidine; Epiboxidine; Nicotine;

D O I：

10.1023/A:1023692705700

中图分类号：

学科分类号：

摘要：

Epibatidine is a natural product that was isolated and identified by Daly and coworkers in 1992. Since that time, it has had a profound influence on the investigation of α4β2 nicotinic cholinergic (nACh) receptor pharmacophore models, and has inspired the development of novel agents with therapeutic potential in CNS disorders. Apart from acetylcholine and nicotine, probably no other agent has had as much recent impact on nACh research as has epibatidine.

引用

页码：365 / 378

页数：13

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