Pathophysiology of tension-type headache

被引：75

作者：

Ashina S. ^{[1
]}

Bendtsen L. ^{[1
]}

Ashina M. ^{[1
]}

机构：

[1] Danish Headache Center, Glostrup Hospital, University of Copenhagen, DK-2600 Glostrup, Copenhagen

来源：

Current Pain and Headache Reports | 2005年 / 9卷 / 6期

关键词：

Central Sensitization; Myofascial Pain; Muscle Blood Flow; Diffuse Noxious Inhibitory Control; Muscle Hardness;

D O I：

10.1007/s11916-005-0021-8

中图分类号：

学科分类号：

摘要：

Tension-type headache is one of the most common primary headache disorders. Advances in basic pain and clinical research have improved our understanding of pathophysiologic mechanisms of tension-type headache. Increased excitability of the central nervous system generated by repetitive and sustained pericranial myofascial input may be responsible for the transformation of episodic tension-type headache into the chronic form. Studies of nitric oxide (NO) mechanisms suggest that NO may play a key role in the pathophysiology of tension-type headache and that the antinociceptive effect of nitric oxide synthase inhibitors may become a novel principle in the future treatment of chronic headache. Future studies should focus on investigation of the source of peripheral nociception, the role of descending pain modulation, and the development of an animal model of tension-type headache to support the pathophysiologic importance of central sensitization in tension-type headache. Copyright © 2005 by Current Science Inc.

引用

页码：415 / 422

页数：7

共 75 条

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