Physiology of the abnormal response of heart failure patients to exercise

被引:2
作者
Cohen-Solal A. [1 ]
Beauvais F. [1 ]
Tabet J.Y. [1 ]
机构
[1] Cardiology Department, Hospital Beaujon, 92110 Clichy
关键词
Cardiol; Chronic Heart Failure; Mitral Regurgitation; Heart Failure Patient; Exercise Capacity;
D O I
10.1007/s11886-004-0020-0
中图分类号
学科分类号
摘要
Chronic heart failure is associated with reduced exercise capacity. Altered diastolic function and reduced chronotropic response play an important role. However, there is no clear correlation between any hemodynamic parameter and exercise capacity. Peripheral factors, long overlooked, seem to play a major role. Altered peripheral vasodilatation, involving endothelial abnormalities, alters the optimal distribution of blood flow. Muscular abnormalities are constant: aside from muscle atrophy, altered muscle metabolism results in an altered utilization of oxygen. A comprehensive understanding of all these determinants of exercise response is important to optimize the care of the patient. Sole improvement of cardiac function may be insufficient to correct their exercise intolerance; regular training may well have beneficial effects on exercise capacity, functional impairment, and quality of life. Copyright © 2004 by Current Science Inc.
引用
收藏
页码:176 / 181
页数:5
相关论文
共 51 条
[1]
Franciosa J., Ziesche S., Wilen H., Functional capacity of patients with chronic left ventricular failure: Relationship of bicycle exercise performance to clinical and hemodynamic characterisation, Am. J. Med., 67, pp. 460-466, (1979)
[2]
Weber K., Kinasewitz G., Janicki J., Fishman A., Oxygen utilisation and ventilation during exercise in patients with chronic cardiac failure, Circulation, 65, pp. 1213-1223, (1982)
[3]
Mancini D., Eisen H., Kussmaul W., Et al., Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients, Circulation, 83, pp. 778-786, (1991)
[4]
Franciosa J., Park M., Levine T., Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure, Am. J. Cardiol., 47, pp. 33-39, (1981)
[5]
Sullivan M.J., Cobb F.R., Central hemodynamic response to exercise in patients with chronic heart failure, Chest, 101, (1992)
[6]
De Groote P., Millaire A., Foucher-Hossein C., Et al., Right ventricular ejection fraction is an independent predictor of survival in patients with moderate heart failure, J. Am. Coll. Cardiol., 32, pp. 948-954, (1998)
[7]
Colucci W., Ribeiro J., Rocco M., Et al., Impaired chronotropic response to exercise in patients with congestive heart failure, Circulation, 80, pp. 314-323, (1989)
[8]
Bristow M., Ginsburg R., Ulmans V., Et al., β1 and β2 adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: Coupling of both receptor subtypes to muscle contraction and selective β1-receptor down-regulation in heart failure, Circ. Res., 59, pp. 297-309, (1986)
[9]
Feldman M., Alderman J., Aroesty J., Et al., Depression of systolic and diastolic myocardial reserve during atrial pacing tachycardia in patients with dilated cardiomyopathy, J. Clin. Invest., 82, pp. 1661-1669, (1988)
[10]
Schmidt U., Schwinger R., Bohm M., Erdmann F., Alterations of the force-frequency relation depending on stages of heart failure in humans, Am. J. Cardiol., 74, pp. 1066-1068, (1994)