Allergenic components of vaccines and avoidance of vaccination-related adverse events

被引:29
作者
Georgitis J.W. [1 ]
Fasano M.B. [1 ]
机构
[1] Medical Center Boulevard, Wake Forest University School of Medicine, Winston-Salem, 27157, NC
关键词
Measle; Pertussis Vaccine; Poliomyelitis; Rabies; Thimerosal;
D O I
10.1007/s11882-001-0091-6
中图分类号
学科分类号
摘要
Vaccines have had a dramatic effect on the prevalence of communicable diseases, but, in selected individuals, the injection presents a risk of anaphylaxis. Fortunately, most people have no allergic reactions to vaccines. In egg-allergic individuals, care must be taken before administering specific vaccines; the algorithm provided in this article gives specific recommendations for skin testing and desensitization. This algorithm is not needed for individuals receiving the measles-mumps-rubella vaccine because the risk of anaphylaxis is extremely low, even in those with known egg-protein sensitivity. Some individuals have gelatin sensitivity, which may cause anaphylaxis. Selected vaccines contain antibiotic drugs, so it is important to note if an individual has any known drug sensitivity, especially to neomycin, polymyxin B, or amphotericin B. Lastly, vaccine preservatives may cause reactions, but this occurs very infrequently. © 2001, Current Science Inc.
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页码:11 / 17
页数:6
相关论文
共 17 条
[1]  
Pickering L.K., Report of the Committee on Infectious Diseases, Red Book, pp. 1-82, (2000)
[2]  
Physicians’ Desk Reference, Edn 54, (2000)
[3]  
Zimmerman B., Zimmerman R.S., Et al., Adverse reactions to vaccines, Allergy: Principles and Practice, pp. 1199-1211, (1998)
[4]  
Mansoor O., Pillans P.I., Vaccine adverse events reported in New Zealand 1990–5, N Z Med J, 110, pp. 270-272, (1997)
[5]  
Chen R.T., Glasser J.W., Rhodes P.H., Et al., Vaccine Safety Datalink project: a new tool for improving vaccine safety monitoring in the United States: the Vaccine Safety Datalink Team, Pediatrics, 99, pp. 765-773, (1997)
[6]  
Fasano M.B., Wood R.A., Cooke S.K., Et al., Egg hypersensitivity and adverse reactions to measles, mumps and rubella vaccine, J Pediatr, 120, pp. 878-881, (1992)
[7]  
Kelso J.M., Jones R.T., Yunginger J.W., Anaphylaxis to measles, mumps and rubella vaccine mediated by IgE to gelatin, J Allergy Clin Immunol, 91, pp. 867-872, (1993)
[8]  
James J.M., Burks A.W., Roberson P.K., Et al., Safe administration of the measles vaccine to children allergic to eggs, N Engl J Med, 332, pp. 1262-1266, (1995)
[9]  
Herman J.J., Radin R., Schneiderman B.S., Allergic reactions to measles (rubeola) vaccine in patients hypersensitive to eggs, J Pediatr, 102, pp. 196-199, (1983)
[10]  
Patrizi A., Rizzoli L., Vincenzi C., Et al., Sensitization to thimerosal in atopic children, Contact Dermatitis, 40, pp. 94-97, (1999)