The HIV infection and immune activation: To fight and burn""

被引：11

作者：

Appay V. ^{[1
]}

Boutboul F. ^{[1
]}

Autran B. ^{[1
]}

机构：

[1] Laboratoire d'Immunologie Cellulaire, Hôpital Pitié-Salpétrière, 75634 Paris Cedex 13

来源：

Current Infectious Disease Reports | 2005年 / 7卷 / 6期

关键词：

Human Immunodeficiency Virus Type; Telomere Length; Immune Activation; Simian Immunodeficiency Virus; Replicative Senescence;

D O I：

10.1007/s11908-005-0050-9

中图分类号：

学科分类号：

摘要：

Immune activation, a normal immune reaction to pathogens, is now recognized as a major driving force of the CD4 T-cell depletion and immune disorders caused by HIV. By contrast, the natural hosts of its ancestor virus, simian immunodeficiency virus, have adapted to this virus by blocking immune activation and remaining healthy. This review will focus on evidence demonstrating how immune activation associated with HIV infection exhausts immune defenses to HIV as well as the immune system, thus leading to immunosenescence and immunodeficiency, and how treatment can disrupt this vicious and ultimately fatal circle. Copyright © 2005 by Current Science Inc.

引用

页码：473 / 479

页数：6

共 50 条

[1] Borkow G., Leng Q., Weisman Z., Et al., Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy, J. Clin. Invest., 106, pp. 1053-1060, (2000)
[2] Giorgi J.V., Hultin L.E., McKeating J.A., Et al., Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage, J. Infect. Dis., 179, pp. 859-870, (1999)
[3] Bentwich Z., Kalinkovich A., Weisman Z., Grossman Z., Immune activation in the context of HIV infection, Clin. Exp. Immunol., 111, pp. 1-2, (1998)
[4] McCune J.M., The dynamics of CD4+ T-cell depiction in HIV disease, Nature, 410, pp. 974-979, (2001)
[5] Hazenberg M.D., Otto S.A., Cohen Stuart J.W., Et al., Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection, Nat. Med., 6, pp. 1036-1042, (2000)
[6] Grossman Z., Meier-Schellersheim M., Sousa A.E., Et al., CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?, Nat. Med., 8, pp. 319-323, (2002)
[7] Silvestri G., Feinberg M.B., Turnover of lymphocytes and conceptual paradigms in HIV infection, J. Clin. Invest., 112, pp. 821-824, (2003)
[8] Silvestri G., Sodora D.L., Koup R.A., Et al., Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia, Immunity, 18, pp. 441-452, (2003)
[9] Monceaux V., Estaquier J., Fevrier M., Et al., Extensive apoptosis in lymphoid organs during primary SIV infection predicts rapid progression towards AIDS, AIDS, 17, pp. 1585-1596, (2003)
[10] Silvestri G., Fedanov A., Germon S., Et al., Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts, J. Virol., 79, pp. 4043-4054, (2005)

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