Free fatty acids, insulin resistance, and pregnancy

被引：92

作者：

Eyal Sivan

Guenther Boden

机构：

[1] Div. of Endocrinol./Diabetes/Metab., Temple University Hospital, Philadelphia, PA 19140

来源：

Current Diabetes Reports | 2003年 / 3卷 / 4期

基金：

美国国家卫生研究院;

关键词：

Insulin Resistance; Free Fatty Acid; Insulin Secretion; Gestational Diabetes Mellitus; Late Pregnancy;

D O I：

10.1007/s11892-003-0024-y

中图分类号：

学科分类号：

摘要：

Acute elevation of plasma free fatty acid (FFA) levels causes insulin resistance to rise dose dependently in pregnant and nonpregnant women. Plasma FFA levels are commonly elevated during late pregnancy, partly due to rising blood levels of lipolytic placental hormones, and are a likely cause for much of the increase in insulin resistance occurring at that time in all pregnant women. Plasma FFA levels are similar or higher and the insulin resistance is comparable or more severe in women with gestational diabetes mellitus (GDM) than in nondiabetic pregnant women. In contrast to healthy pregnant women, insulin secretion in women with GDM is defective and, therefore, is unable to rise adequately to compensate for the insulin resistance; the result is hyperglycemia. The mechanism by which elevated plasma FFA levels cause insulin resistance in skeletal muscle includes intramyocellular accumulation of diacylglycerol, which activates protein kinase C (the β II and δ isoforms). This results in reduction of tyrosine phosphorylation of the insulin receptor substrate-1 and inhibits activation of phosphoinositol-3 kinase, an enzyme that is essential for normal insulin-stimulated glucose uptake. Copyright © 2003 by Current Science Inc.

引用

页码：319 / 322

页数：3

共 43 条

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