Structure of the 30S ribosomal subunit

被引：1631

作者：

Wimberly B.T. ^{[1
]}

Brodersen D.E. ^{[1
]}

Clemons Jr. W.M. ^{[1
,2
]}

Morgan-Warren R.J. ^{[1
]}

Carter A.P. ^{[1
]}

Vonrheln C. ^{[3
]}

Hartsch T. ^{[4
]}

Ramakrishnan V. ^{[1
]}

机构：

[1] MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, Hills Road

[2] Department of Biochemistry, Univ. of Utah School of Medicine, Salt Lake City

[3] Global Phasing Ltd., Sheraton House, Cambridge CB3 0AX, Castle Park

[4] Göttingen Genomics Laboratory, Inst. F. Mikrobiologie und Genetik, Georg-August-Univ. Göttingen, D-37077 Göttingen

来源：

Nature | 2000年 / 407卷 / 6802期

关键词：

D O I：

10.1038/35030006

中图分类号：

学科分类号：

摘要：

Genetic information encoded in messenger RNA is translated into protein by the ribosome, which is a large nucleoprotein complex comprising two subunits, denoted 30S and 50S in bacteria. Here we report the crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 Å resolution. The final atomic model rationalizes over four decades of biochemical data on the ribosome, and provides a wealth of information about RNA and protein structure, protein-RNA interactions and ribosome assembly. It is also a structural basis for analysis of the functions of the 30S subunit, such as decoding, and for understanding the action of antibiotics. The structure will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography.

引用

页码：327 / 339

页数：12

共 51 条

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