Inflammation and diabetic nephropathy

被引：231

作者：

Mora C. ^{[1
]}

Navarro J.F. ^{[1
]}

机构：

[1] Nephrology Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife

来源：

Current Diabetes Reports | 2006年 / 6卷 / 6期

关键词：

Diabetic Nephropathy; Renal Injury; Pentoxifylline; Urinary Albumin Excretion; European Prospective Investigation Into Cancer;

D O I：

10.1007/s11892-006-0080-1

中图分类号：

学科分类号：

摘要：

Diabetic nephropathy has become the main cause of renal failure, but unfortunately the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, different inflammatory molecules, including chemokines, adhesion molecules, and proinflammatory cytokines, may be critical factors in the development of microvascular diabetic complications, including nephropathy. This new pathogenic perspective leads to important therapeutic considerations, with new pathogenic pathways becoming important therapeutic targets that can be translated into clinical treatments for diabetic nephropathy. Copyright © 2006 by Current Science Inc.

引用

页码：463 / 468

页数：5

共 78 条

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