Rising birth prevalence of gastroschisis

被引：98

作者：

Matthew Laughon

Robert Meyer

Carl Bose

Alison Wall

Eduardo Otero

Ann Heerens

Reese Clark

机构：

[1] Division Neonatal-Perinatal Medicine, University of North Carolina, UNC Hospital, Chapel Hill

[2] State Center for Health Statistics, Raleigh, NC

[3] Broward General Medical Center, Fort Lauderdale, FL

[4] Pediatrix Medical Group Inc., Sunrise, FL

来源：

Journal of Perinatology | 2003年 / 23卷 / 4期

关键词：

D O I：

10.1038/sj.jp.7210896

中图分类号：

学科分类号：

摘要：

Objective: Gastroschisis is a congenital anomaly that has been reported to be increasing in frequency. The objective of this study was to determine the birth prevalence of gastroschisis using two large databases. Study Design: We reviewed data from a statewide database and a national database from a neonatal health care provider, abstracting cases of gastroschisis. Results: In North Carolina, the birth prevalence of gastroschisis increased from 1.96 per 10,000 births in 1997 to 4.49 per 10,000 births in 2000 (p = 0.0007). The overall increase was almost entirely because of the increase in infants born to mothers less than 20 years old. Among infants receiving care from the national neonatal provider, the prevalence of gastroschisis increased from 2.9 per 1000 patients in 1997 to five per 1000 patients in 2001 (p = 0.044). Conclusion: The birth prevalence of gastroschisis is increasing in North Carolina, and this trend may be occurring nationally. The rapid change in the birth prevalence in the subset of population most at risk for gastroschisis implicates environmental or pharmacologic teratogens rather than changing population characteristics as a causal factor in the development of gastroschisis.

引用

页码：291 / 293

页数：2

共 15 条

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