Modulation of inflammatory mediators by coumarinolignoids from Cleome viscosa in female swiss albino mice

被引：38

作者：

Bawankule D.U. ^{[1
]}

Chattopadhyay S.K. ^{[2
]}

Pal A. ^{[1
]}

Saxena K. ^{[1
]}

Yadav S. ^{[1
]}

Faridi U. ^{[1
]}

Darokar M.P. ^{[1
]}

Gupta A.K. ^{[1
]}

Khanuja S.P.S. ^{[1
]}

机构：

[1] Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow-226015, Kukrail Picnic Spot Road

[2] Products and Process Development Division, Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow

来源：

Inflammopharmacology | 2008年 / 16卷 / 6期

关键词：

Coumarinolignoids; Inflammation; Macrophages; Mice; Spleenocytes;

D O I：

10.1007/s10787-008-8012-0

中图分类号：

学科分类号：

摘要：

The effect of coumarinolignoid cleomiscosins A, B and C isolated from the plant Cleome viscosa on inflammatory mediators were studied in female swiss albino mice. A mixture of coumarinolignoid A, B, and C at 10, 30 and 100 mg/kg body weight once a day for 14 consecutive days were administered orally to the mice. Pro-inflammatory mediators such as IL-6, TNF-α and nitric oxide were estimated from culture supernatant obtained from peritoneal macrophages stimulated by LPS and anti-inflammatory mediator IL-4 was estimated from culture supernatant obtained from spleenocytes stimulated by Con-A. For further confirmation, expressions of inflammatory mediators from serum and mortality rate were studied in LPS-induced toxicity model in mice. The expression of Pro-inflammatory mediators was significantly (P <0.05) decreased in coumarinolignoids treatment group in dose dependent manner, whereas the anti-inflammatory mediator expression was significantly increased in coumarinolignoids at 10 mg/kg treatment. Mortality rate was also significantly reduced in treatment group in LPS-induced toxicity model. The result of this study concluded that the oral administration of coumarinolignoids inhibited the pro-inflammatory mediators and enhances the production of anti-inflammatory mediator in dose dependent manner. © 2008 Birkhäuser Verlag.

引用

页码：272 / 277

页数：5

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