Mechanisms underlying visceral hypersensitivity in irritable bowel syndrome

被引：111

作者：

Barbara G. ^{[1
,2
]}

Cremon C. ^{[1
]}

De Giorgio R. ^{[1
]}

Dothel G. ^{[1
]}

Zecchi L. ^{[1
]}

Bellacosa L. ^{[1
]}

Carini G. ^{[1
]}

Stanghellini V. ^{[1
]}

Corinaldesi R. ^{[1
]}

机构：

[1] Department of Clinical Medicine, Center for Applied Biomedical Research (CRBA), University of Bologna, Bologna

[2] Department of Clinical Medicine, St. Orsola-Malpighi Hospital, Building #5, Bologna 40138, Via Massarenti

来源：

Current Gastroenterology Reports | 2011年 / 13卷 / 4期

关键词：

Abdominal pain; Enterochromaffin cells; Epithelial permeability; Immune cells; Irritable bowel syndrome; Microbiota; Sensory afferents; Visceral hypersensitivity;

D O I：

10.1007/s11894-011-0195-7

中图分类号：

学科分类号：

摘要：

Visceral hypersensitivity is currently considered a key pathophysiological mechanism involved in pain perception in large subgroups of patients with functional gastrointestinal disorders, including irritable bowel syndrome (IBS). In IBS, visceral hypersensitivity has been described in 20%-90% of patients. The contribution of the central nervous system and psychological factors to visceral hypersensitivity in patients with IBS may be significant, although still debated. Peripheral factors have gained increasing attention following the recognition that infectious enteritis may trigger the development of persistent IBS symptoms, and the identification of mucosal immune, neural, endocrine, microbiological, and intestinal permeability abnormalities. Growing evidence suggests that these factors play an important role in pain transmission from the periphery to the brain via sensory nerve pathways in large subsets of patients with IBS. In this review, we will report on recent data on mechanisms involved in visceral hypersensitivity in IBS, with particular attention paid to peripheral mechanisms. © 2011 Springer Science+Business Media, LLC.

引用

页码：308 / 315

页数：7

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