Enhancement in seroconversion to measles vaccine with simultaneous administration of vitamin A in 9-months-old Indian infants

被引：37

作者：

Bhaskaram P. ^{[1
,2
]}

Rao K.V. ^{[1
]}

机构：

[1] Depts. of Pediatrics and Statistics, National Institute of Nutrition, Indian Council of Medical Research, Hyderabad

[2] Depts. of Pediatrics and Statistics, National Institute of Nutrition, Indian Council of Medical Research, Jamai-Osmania

来源：

The Indian Journal of Pediatrics | 1997年 / 64卷 / 4期

关键词：

Child survival; EZ strain; Measles vaccine; Vitamin A;

D O I：

10.1007/BF02737757

中图分类号：

学科分类号：

摘要：

The mutual interactions of measles vaccine and vitamin A dose when administered simultaneously to 9 month old infants are explored in this study. One hundred healthy infants of 9 months of age received EZ strain of measles vaccine in the routine immunization clinic with either 100,000 IU of vitamin A or a placebo orally. Blood samples were collected before and 4 weeks after intervention. They were coded and analysed for serum retinol and Hemagglutination Inhibition (HI) antibodies to measles. Ninety five per cent of the infants seronegative to measles prior to vaccination with a seroconversion rate of 63% in the control group and a significantly higher percent of 83.7% in the experimental group (P < 0.01). Seroconversion was not related to initial serum retinol levels in either of the groups. 42% of infants had serum retinol levels less than 20 ug/dl before administration of the vaccine and both the groups showed improvement in vitamin A status following intervention, the increase being significant in the experimental group (from 22.4 ± 1.32 to 26.0 ± 1.07; P < 0.05). The results indicate that majority of the infants at 9 months of age were seronegative to measles. Seroconversion of measles vaccine in the routine immunization clinics was low. Simultaneous administration of vitamin A and measles vaccine had beneficial effects on Vitamin A status as well as seroconversion rates to the vaccine in 9 months old infants.

引用

页码：503 / 509

页数：6

共 23 条

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