Role of APC and DNA mismatch repair genes in the development of colorectal cancers

被引：127

作者：

Satya Narayan

Deodutta Roy

机构：

[1] Department of Anatomy/Cell Biology, UF Shands Cancer Center, University of Florida, Gainesville, FL 32610

[2] Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-0022

来源：

Molecular Cancer | / 2卷 / 1期

关键词：

Familial Adenomatous Polyposis; Adenomatous Polyposis Coli; Familial Adenomatous Polyposis Patient; Adenomatous Polyposis Coli Gene; Adenomatous Polyposis Coli Protein;

D O I：

10.1186/1476-4598-2-41

中图分类号：

学科分类号：

摘要：

Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S. in 2003, accounting for about 10% of cancer deaths. Among the colon cancer patients, hereditary risk contributes approximately 20%. The main inherited colorectal cancers are the familial adenomatous polyposis (FAP) and the hereditary nonpolyposis colorectal cancers (HNPCC). The FAP and HNPCC are caused due to mutations in the adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes. The focus of this review is to summarize the functions of APC and MMR gene products in the development of colorectal cancers. © 2003 Narayan and Roy; licensee BioMed Ltd.

引用

页数：15

共 143 条

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