Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane

被引：145

作者：

Ian J Russell ^{[1
]}

P Kevin Legan ^{[1
]}

Victoria A Lukashkina ^{[1
]}

Andrei N Lukashkin ^{[1
]}

Richard J Goodyear ^{[1
]}

Guy P Richardson ^{[1
]}

机构：

[1] School of Life Sciences, University of Sussex, Falmer, Brighton

来源：

Nature Neuroscience | 2007年 / 10卷 / 2期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nn1828

中图分类号：

学科分类号：

摘要：

Frequency tuning in the cochlea is determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells, sensory-effector cells that detect and amplify sound-induced basilar membrane motions. The sensory hair bundles of the outer hair cells are imbedded in the tectorial membrane, a sheet of extracellular matrix that overlies the cochlea's sensory epithelium. The tectorial membrane contains radially organized collagen fibrils that are imbedded in an unusual striated-sheet matrix formed by two glycoproteins, α-tectorin (Tecta) and β-tectorin (Tectb). In Tectb-/- mice the structure of the striated-sheet matrix is disrupted. Although these mice have a low-frequency hearing loss, basilar-membrane and neural tuning are both significantly enhanced in the high-frequency regions of the cochlea, with little loss in sensitivity. These findings can be attributed to a reduction in the acting mass of the tectorial membrane and reveal a new function for this structure in controlling interactions along the cochlea. © 2007 Nature Publishing Group.

引用

页码：215 / 223

页数：8

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