The biology of the Ets1 proto-oncogene

被引：364

作者：

Jürgen Dittmer

机构：

[1] Universität Helle-Wittenberg, Univ./Poliklinik fur Gynakologie, 06097 Halle Saale

来源：

关键词：

Vascular Endothelial Growth Factor; Hepatocyte Growth Factor; Vascular Endothelial Growth Factor Receptor; Ets1 Protein; Ets1 Gene;

D O I：

10.1186/1476-4598-2-29

中图分类号：

学科分类号：

摘要：

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. Some transcription factors, such as AML-1, regulate Ets1 by targeting its autoinhibitory module. Others, such as Pax-5, alter Ets1 DNA binding properties. Ets1 harbors two phosphorylation sites, threonine-38 and an array of serines within the exon VII domain. Phosphorylation of threonine-38 by ERK1/2 activates Ets1, whereas phosphorylation of the exon VII domain by CaMKII or MLCK inhibits Ets1 DNA binding activity. Ets1 is expressed by numerous cell types. In haemotopoietic cells, it contributes to the regulation of cellular differentiation. In a variety of other cells, including endothelial cells, vascular smooth muscle cells and epithelial cancer cells, Ets1 promotes invasive behavior. Regulation of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGF receptor gene expression has been ascribed to Ets1. In tumors, Ets1 expression is indicative of poorer prognosis. © 2003 Dittmer; licensee BioMed Central Ltd.

引用

页数：21

共 154 条

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