Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertension

被引：6

作者：

Ambalavanan N. ^{[1
]}

St. John E. ^{[1
]}

Carlo W.A. ^{[1
]}

Bulger A. ^{[1
]}

Philips III J.B. ^{[1
]}

机构：

[1] University of Alabama at Birmingham, Division of Neonatology, Department of Pediatrics, Birmingham, AL 35249-6098

来源：

Journal of Perinatology | 2002年 / 22卷 / 1期

关键词：

D O I：

10.1038/sj.jp.7210652

中图分类号：

学科分类号：

摘要：

Objective: To test the hemodynamic efficacy and feasibility of nitric oxide (NO) administration by oxygen hood in neonatal pulmonary hypertension. Study Design: A double-hood apparatus was used in which a combination of NO, O2, and N2 was introduced into the inner hood and suctioned from the outer hood. Chronically instrumented non-intubated piglets were exposed to 10% O2 (hypoxia; n = 8) or group B streptococci infusion (GBS; n = 5) to produce pulmonary hypertension and were then exposed to 20 ppm NO. Results: NO decreased ( > 50%) pulmonary artery pressure and vascular resistance in both hypoxia- and GBS-induced pulmonary hypertension, with minimal effects on systemic arterial pressure and cardiac output. NO administration could be performed without detectable environmental leakage. Conclusion: Hood NO administration is feasible and shows hemodynamic efficacy in neonatal piglets with pulmonary hypertension.

引用

页码：50 / 56

页数：6

共 22 条

[1]

Walsh-Sukys M.C., Persistent pulmonary hypertension of the newborn. The black box revisited, Clin. Perinatol., 20, pp. 127-143, (1993)

[2]

Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure, N. Engl. J. Med., 336, pp. 597-604, (1997)

[3]

Kinsella J.P., Truog W.E., Walsh W.F., Et al., Randomized multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn, J. Pediatr., 131, pp. 55-62, (1997)

[4]

Rosenberg A.A., Kennaugh J.M., Moreland S.G., Et al., Longitudinal follow-up of a cohort of newborn infants treated with inhaled nitric oxide for persistent pulmonary hypertension, J. Pediatr., 131, pp. 70-75, (1997)

[5]

Wessel D.L., Adatia I., Van Marter L.J., Et al., Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn, Pediatrics, 100, (1997)

[6]

Roberts J.D., Fineman J.R., Morin F.C. III, Et al., Inhaled nitric oxide and persistent pulmonary hypertension of the newborn, N. Engl. J. Med., 336, pp. 605-610, (1997)

[7]

Davidson D., Barefield E.S., Kattwinkel J., Et al., Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: A randomized, double-masked, placebo-controlled, dose-response, multicenter study, Pediatrics, 101, pp. 325-334, (1998)

[8]

Truog W.E., Inhaled nitric oxide: A tenth anniversary observation, Pediatrics, 101, pp. 696-697, (1998)

[9]

Bancalari E., Gerhardt T., Bronchopulmonary dysplasia, Pediatr. Clin. North Am., 33, pp. 1-23, (1986)

[10]

Mariani G.L., Carlo W.A., Ventilatory management in neonates. Science or art?, Clin. Perinatol., 25, pp. 33-48, (1998)

← 1 2 3 →