New insights on the pathogenesis of invasive Cryptococcus neoformans infection

被引：47

作者：

Eisenman H.C. ^{[1
]}

Casadevall A. ^{[1
]}

McClelland E.E. ^{[1
]}

机构：

[1] Albert Einstein College of Medicine, Bronx, NY 10461

来源：

Current Infectious Disease Reports | 2007年 / 9卷 / 6期

关键词：

Cryptococcus Neoformans; Cryptococcosis; Brain Microvascular Endothelial Cell; Phenotypic Switching; Fungal Burden;

D O I：

10.1007/s11908-007-0070-8

中图分类号：

学科分类号：

摘要：

Disseminated cryptococcosis begins with infection of the lungs via inhalation. This is followed by escape from the lungs and entry into the bloodstream allowing dissemination to the brain and central nervous system. We discuss the steps involved in dissemination and the host and microbial factors that influence each step. For the host, containment in the lung is accomplished with a combination of cell-mediated and antibody responses. Dissemination occurs when these systems fail and/or when phagocytic cells that fail to kill the yeast instead act as a niche for replication. One of the main microbial factors affecting dissemination is the polysaccharide capsule, a major virulence factor that promotes dissemination at every step. Secreted enzymes are important, including laccase and phospholipase B, which promote escape from the lungs, and urease, which contributes to crossing the blood-brain barrier. Lastly, a number of regulatory factors contribute, especially to growth of Cryptococcus neoformans in the brain. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：457 / 464

页数：7

共 50 条

[1]

Wilder J.A., Olson G.K., Chang Y.C., Et al., Complementation of a capsule deficient Cryptococcus neoformans with CAP64 restores virulence in a murine lung infection, Am J Respir Cell Mol Biol, 26, pp. 306-314, (2002)

[2]

Noverr M.C., Williamson P.R., Fajardo R.S., Huffnagle G.B., CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence, Infect Immun, 72, pp. 1693-1699, (2004)

[3]

Olszewski M.A., Noverr M.C., Chen G.H., Et al., Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion, Am J Pathol, 164, pp. 1761-1771, (2004)

[4]

Huffnagle G.B., Toews G.B., Burdick M.D., Et al., Afferent phase production of TNF-alpha is required for the development of protective T cell immunity to Cryptococcus neoformans, J Immunol, 157, pp. 4529-4536, (1996)

[5]

Kawakami K., Tohyama M., Teruya K., Et al., Contribution of interferon-gamma in protecting mice during pulmonary and disseminated infection with Cryptococcus neoformans, FEMS Immunol Med Microbiol, 13, pp. 123-130, (1996)

[6]

Kawakami K., Qureshi M.H., Zhang T., Et al., IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production, J Immunol, 159, pp. 5528-5534, (1997)

[7]

Miyagi K., Kawakami K., Kinjo Y., Et al., CpG oligodeoxy-nucleotides promote the host protective response against infection with Cryptococcus neoformans through induction of interferon-gamma production by CD4+ T cells, Clin Exp Immunol, 140, pp. 220-229, (2005)

[8]

Feldmesser M., Casadevall A., Effect of serum IgG1 to Cryptococcus neoformans glucuronoxylomannan on murine pulmonary infection, J Immunol, 158, pp. 790-799, (1997)

[9]

Maitta R.W., Datta K., Chang Q., Et al., Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus ncoformans glucuronoxylomannan manifest different specificities and gene use profiles, Infect Immun, 72, pp. 4810-4818, (2004)

[10]

Rivera J., Zaragoza O., Casadevall A., Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells, Infect Immun, 73, pp. 1141-1150, (2005)

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