A standard procedure for creating a frailty index

被引：2272

作者：

Searle S.D. ^{[1
]}

Mitnitski A. ^{[1
,2
,3
]}

Gahbauer E.A. ^{[4
]}

Gill T.M. ^{[4
]}

Rockwood K. ^{[1
,2
,5
]}

机构：

[1] Geriatric Medicine Research Unit, Dalhousie University, Capital District Health Authority, Halifax, NS

[2] Department of Medicine, Dalhousie University, Halifax, NS

[3] Department of Mathematics and Statistics, Dalhousie University, Halifax, NS

[4] Department of Internal Medicine, Yale University School of Medicine, New Haven

[5] Division of Geriatric Medicine, Dalhousie University, Halifax, NS

来源：

BMC Geriatrics | / 8卷 / 1期

基金：

加拿大健康研究院;

关键词：

Mild Cognitive Impairment; Frailty Index; Frailty State; Baseline Cohort; Health Deficit;

D O I：

10.1186/1471-2318-8-24

中图分类号：

学科分类号：

摘要：

Background. Frailty can be measured in relation to the accumulation of deficits using a frailty index. A frailty index can be developed from most ageing databases. Our objective is to systematically describe a standard procedure for constructing a frailty index. Methods. This is a secondary analysis of the Yale Precipitating Events Project cohort study, based in New Haven CT. Non-disabled people aged 70 years or older (n = 754) were enrolled and re-contacted every 18 months. The database includes variables on function, cognition, co-morbidity, health attitudes and practices and physical performance measures. Data came from the baseline cohort and those available at the first 18-month follow-up assessment. Results. Procedures for selecting health variables as candidate deficits were applied to yield 40 deficits. Recoding procedures were applied for categorical, ordinal and interval variables such that they could be mapped to the interval 0-1, where 0 = absence of a deficit, and 1= full expression of the deficit. These individual deficit scores were combined in an index, where 0= no deficit present, and 1= all 40 deficits present. The values of the index were well fit by a gamma distribution. Between the baseline and follow-up cohorts, the age-related slope of deficit accumulation increased from 0.020 (95% confidence interval, 0.014-0.026) to 0.026 (0.020-0.032). The 99% limit to deficit accumulation was 0.6 in the baseline cohort and 0.7 in the follow-up cohort. Multivariate Cox analysis showed the frailty index, age and sex to be significant predictors of mortality. Conclusion. A systematic process for creating a frailty index, which relates deficit accumulation to the individual risk of death, showed reproducible properties in the Yale Precipitating Events Project cohort study. This method of quantifying frailty can aid our understanding of frailty-related health characteristics in older adults. © 2008 Searle et al; licensee BioMed Central Ltd.

引用

共 34 条

[1]

Bergman H., Ferrucci L., Guralnik J., Hogan D.B., Hummel S., Karunananthan S., Wolfson C., Frailty: An emerging research and clinical paradigm-issues and controversies, J Gerontol a Biol Sci Med Sci, 62, pp. 731-737, (2007)

[2]

Fisher A.L., Just what defines frailty?, J Am Geriatr Soc, 53, pp. 2229-2230, (2005)

[3]

Whitson H.E., Purser J.L., Cohen H.J., Frailty thy name is . Phrailty?, J Gerontol a Biol Sci Med Sci, 62, 7, pp. 728-730, (2007)

[4]

Mitnitski A.B., Mogilner A.J., Rockwood K., Accumulation of deficits as a proxy measure of aging, The Scientific World, 1, pp. 323-336, (2001)

[5]

Rockwood K., Mitnitski A., Frailty in relation to the accumulation of deficits, J Gerontol Biol Sci Med Sci, 62, pp. 722-727, (2007)

[6]

Mitnitski A., Xiaowei S., Skoog I., Broe G.A., Cox J.L., Grunfeld E., Rockwood K., Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality, J Am Geriatr Soc, 53, 12, pp. 2184-5189, (2005)

[7]

Rockwood K., Andrew M., Mitnitski A., A Comparison of two approaches to measuring frailty in elderly people, J Gerontol a Biol Sci Med Sci, 62, 7, pp. 738-743, (2007)

[8]

Kulminski A., Yashin A., Arbeev K., Akushevich I., Ukraintseva S., Land K., Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: Results from analyses of the National Long Term Care Survey, Mech Ageing Dev, 128, pp. 250-258, (2007)

[9]

Kulminski A., Ukraintseva S.V., Akushevich I.V., Arbeev K.G., Yashin A.I., Cumulative index of health deficiencies as a characteristic of long life, J Am Geriatr Soc, 55, 6, pp. 935-40, (2007)

[10]

Goggins W.B., Woo J., Sham A., Ho S.C., Frailty index as a measure of personal biological age in a Chinese population, J Gerontol a Biol Sci Med Sci, 60, pp. 1046-1051, (2005)

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