How much food is too much? Threshold doses for allergenic foods.

被引：12

作者：

Hefle S.L. ^{[1
]}

Taylor S.L. ^{[1
]}

机构：

[1] Food Allergy Research and Resource Program, University of Nebraska, 351 Food Industry Complex, Lincoln, 68583-0919, NE

来源：

Current Allergy and Asthma Reports | 2002年 / 2卷 / 1期

关键词：

Food Allergy; Allergy Clin Immunol; Threshold Dose; Peanut Allergy; Consumer Complaint;

D O I：

10.1007/s11882-002-0041-y

中图分类号：

学科分类号：

摘要：

This review summarizes recent findings and controversies in the area of threshold doses for allergenic foods. Over the years, there have been many clinical reports that ingestion of small amounts of food can elicit IgE-mediated allergic reactions. In exquisitely allergic individuals, the threshold dose for elicitation of such reactions is often considered to be zero. However, some food-allergic patients report that they can tolerate small quantities of allergenic food. Are very low quantities hazardous to food-allergic consumers? How much of the offending food is too much? Why is the concept of a threshold level important? There have been very few studies to date on threshold doses for allergenic foods, and more research is needed in this important area.

引用

页码：63 / 66

页数：3

共 30 条

[1] Bock SA(2000)Fatalities due to anaphylactic reactions to foods J Allergy Clin Immunol 107 191-193
[2] Munoz-Furlong A(1998)Food manufacturing initiatives to protect the allergic consumer Allergy 53 89-92
[3] Sampson HA(1988)Fatal foodinduced anaphylaxis JAMA 260 1450-1452
[4] Huggett AC(1992)Fatal and near-fatal anaphylactic reactions to food in children and adolescents N Engl J Med 327 380-384
[5] Hischenhuber C(2001)The threshold concept in food safety and its applicability to food allergy Allergy 67 86-90
[6] Yunginger JW(1997)An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study J Allergy Clin Immunol 100 596-600
[7] Sweeney KG(2000)Peanut allergy in children: skin prick test, specific IgE and dose response by double-blind placebo-controlled food challenge [abstract] Allergy 55 55-55
[8] Sturner WQ(1992)Codfish allergy in adults. Identification and diagnosis Allergy 47 610-617
[9] Sampson HA(2001)Threshold dose for egg allergy determined by oral challenge [abstract] J Allergy Clin Immunol 107 S231-S231
[10] Mendelson L(1999)Prevalence of peanut and tree nut allergy in the US determined by a random digit dial telephone survey J Allergy Clin Immunol 103 559-562

← 1 2 3 →