Intracranial atherosclerotic stroke: Specific focus on the metabolic syndrome and inflammation

被引：21

作者：

Bang O.Y. ^{[1
]}

机构：

[1] Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, 50 Irwon-dong, Gangnam-gu

来源：

Current Atherosclerosis Reports | 2006年 / 8卷 / 4期

关键词：

Metabolic Syndrome; Ischemic Stroke; Arterioscler Thromb Vasc Biol; Metabolic Risk Factor; Insulin Resistance Syndrome;

D O I：

10.1007/s11883-006-0012-1

中图分类号：

学科分类号：

摘要：

Stroke is the second leading cause of mortality worldwide and is well suited for prevention because it has a high prevalence, high burden of economic cost, well-defined modifiable risk factors, and effective prevention measures. Atherosclerosis is one of the major mechanisms of ischemic stroke, but the apparent differences in risk factors for intra- and extracranial atherosclerosis are unclear and the mechanisms that underlie strokes in patients with intracranial atherosclerosis are not well known. Consequently, patients with intracranial stenosis receive the same treatment as those with carotid atherosclerosis. Several novel substances have emerged recently as risk factors for atherosclerosis. Specifically, it has recently been suggested that both the metabolic syndrome, which refers to a constellation of metabolic risk factors that are linked to insulin resistance, and vascular inflammation are associated with increased risk of coronary heart disease and stroke. The results of the studies reviewed here suggest that these factors play a differential role in the development of atherosclerotic stroke between the intra- and extracranial arterial systems. Copyright © 2006 by Current Science Inc.

引用

页码：330 / 336

页数：6

共 65 条

[1]

Zimmet P., Global and social implications of the diabetes epidemic, Nature, 414, pp. 82-787, (2001)

[2]

Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Final report, Circulation, 106, pp. 3143-3421, (2002)

[3]

Sacco R.L., Kargman D.E., Gu Q., Zamanillo M.C., Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study, Stroke, pp. 2614-2620, (1995)

[4]

Wityk R.J., Lehman D., Klag M., Et al., Race and sex differences in the distribution of cerebral atherosclerosis, Stroke, 27, pp. 1974-1980, (1996)

[5]

Wong K.S., Huang Y.N., Gao S., Et al., Intracranial stenosis in Chinese patients with acute stroke, Neurology, 50, pp. 812-813, (1998)

[6]

Moossy J., Morphology, sites and epidemiology of cerebral atherosclerosis, Res Publ Assoc Res Nerv Ment Dis, 41, pp. 1-22, (1966)

[7]

Mitchell J.R., Schwartz C.J., Relationship between arterial disease in different sites. A study of the aorta and coronary, carotid, and iliac arteries, BMJ, 5288, pp. 1293-1301, (1962)

[8]

Bang O.Y., Lee P.H., Yoon S.R., Et al., Inflammatory markers, rather than conventional risk factors, are different between carotid and MCA atherosclerosis, J Neurol Neurosurg Psychiatry, 76, pp. 1128-1134, (2005)

[9]

Akins P.T., Pilgram T.K., Cross III D.T., Moran C.J., Natural history of stenosis from intracranial atherosclerosis by serial angiography, Stroke, 29, pp. 433-438, (1998)

[10]

Tanimoto S., Ikari Y., Tanabe K., Et al., Prevalence of carotid artery stenosis in patients with coronary artery disease in Japanese population, Stroke, 36, pp. 2094-2098, (2005)

← 1 2 3 4 5 6 7 →