Bladder dysfunction and parkinsonism: Current pathophysiological understanding and management strategies

被引：16

作者：

Campeau L. ^{[1
]}

Soler R. ^{[2
]}

Andersson K.-E. ^{[1
]}

机构：

[1] Institute for Regenerative Medicine, Wake Forest University, School of Medicine, Winston Salem, NC 27157, Medical Center Boulevard

[2] Division of Urology, University of São Paulo, School of Medicine, 01246903 São Paulo, Av. Dr. Arnaldo no. 455, Cerqueira César

来源：

Current Urology Reports | 2011年 / 12卷 / 6期

关键词：

Autonomic symptoms; Bladder dysfunction; Incontinence; Lower urinary tract symptoms; LUTS; Nocturia; Overactive bladder; Parkinson's disease; Parkinsonism; Urinary frequency;

D O I：

10.1007/s11934-011-0219-8

中图分类号：

学科分类号：

摘要：

Patients with Parkinson's disease (PD) commonly develop lower urinary tract symptoms (LUTS) as their disease severity progresses. It is a well-established fact that neurodegeneration of the nigrostriatal dopaminergic pathway occurs in PD. This neurochemical deficiency explains many of the motor disturbances encountered in patients with PD. However, the underlying cause of urinary dysfunction present in over half of patients with PD is poorly understood. Without clearly understanding the underlying pathophysiological and neurochemical mechanisms of LUTS associated with PD, treatment strategies are mainly empirical in nature. This review presents the most recent studies and evidence on the pathophysiological mechanisms of PD-related voiding dysfunction and its available therapies. © 2011 Springer Science+Business Media, LLC.

引用

页码：396 / 403

页数：7

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