The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: Insights for clinicians

被引：23

作者：

Klöppel G. ^{[1
]}

Lüttges J. ^{[1
]}

机构：

[1] Department of Pathology, University of Kiel, 24105 Kiel

来源：

Current Gastroenterology Reports | 2004年 / 6卷 / 2期

关键词：

Pancreatic Duct; Intraductal Papillary Mucinous Neoplasm; Mucinous Cystic Neoplasm; Familial Pancreatic Cancer; Pancreatic Duct System;

D O I：

10.1007/s11894-004-0037-y

中图分类号：

学科分类号：

摘要：

The phenotypic classification of pancreatic neoplasms is based on their cellular lineage. Thus, tumors with a ductal, acinar, and endocrine phenotype can be distinguished. Most pancreatic neoplasms show a ductal phenotype and can be classified as ductal adenocarcinomas. Less common tumors with a ductal phenotype are the variants of ductal adenocarcinoma, intraductal papillary mucinous neoplasm (including colloid carcinoma), mucinous cystic neoplasm, medullary carcinoma, and other rare tumors. Ductal adenocarcinomas most likely develop from ductal proliferative lesions arising in the pancreatic duct system. A recently adopted classification system for these lesions distinguishes between three grades of pancreatic intraepithelial neoplasia (PanIN). Molecular studies have revealed that PanIN-2 and PanIN-3 lesion represent a distinct step toward invasive carcinoma. Copyright © 2004 by Current Science Inc.

引用

页码：111 / 118

页数：7

共 69 条

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