Ultra-fast biosensors and multi-photon microscopy in the future of brain studies

被引：3

作者：

Rumiana Bakalova ^{[1
]}

机构：

[1] On-Site Sensing and Diagnosis Research Laboratory, AIST-Kyushy, Tosu, Saga 841-0052

[2] Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba

来源：

Cellular and Molecular Neurobiology | 2007年 / 27卷 / 3期

关键词：

Biosensors; Function/flow coupling; Multi-photon microscopy; Neuroscience;

D O I：

10.1007/s10571-006-9129-6

中图分类号：

学科分类号：

摘要：

The direct, highly selective and sensitive real-time imaging of neuro- and biochemical mediators is the only way to clarify precisely the chemistry of the brain and to discover the key molecular targets involved in regulation of brain homeostasis. To realize that, we need: high-speed deep-tissue imaging techniques with high spatial and temporal resolution; and ultra-fast and highly selective molecular sensors, giving a possibility to monitor target molecules directly in their physiological environment; in addition, these molecular sensors have to be comparatively small and permeable for blood-brain barrier, to be applicable in brain studies. The present view accents on the perspectives for development of direct approach for investigation of function/flow coupling phenomenon in the brain, based on the current progress in development of ultra-fast molecular sensors for direct visualization of biochemical mediators (e.g., nitric oxide, Ca ions), and high-speed two-photon/multi-photon deep-tissue imaging. © 2006 Springer Science+Business Media, LLC.

引用

页码：359 / 365

页数：6

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