Genetic determinants of C-reactive protein

被引：29

作者：

Suk Danik J. ^{[1
]}

Ridker P.M. ^{[1
]}

机构：

[1] Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215

来源：

Current Atherosclerosis Reports | 2007年 / 9卷 / 3期

关键词：

Single Nucleotide Polymorphism; Arterioscler Thromb Vasc Biol; Mendelian Randomization; Affect Transcription Factor Binding; NHLBI Family Heart Study;

D O I：

10.1007/s11883-007-0019-2

中图分类号：

学科分类号：

摘要：

C-reactive protein iCRP) levels are a complex phenotype with bowth genetic and environmental determinants. Recent work has highlighted the impact of genetic variants within the CRP gene as well as other candidate genes, often chosen for their role in the inflammatory pathway, on CRP levels. Emerging work shows the association of such genetic variants in CRP not only to CRP levels, but also to variation of CRP levels in the acute phase response. Work on the relation of genetic variants within CRP to cardiovascular disease has had varied results. Whole-genome association studies to investigate the genetic determinants of CRP levels in an unbiased manner are ongoing. © 2007 by Current Medicine Group LLC.

引用

页码：195 / 203

页数：8

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