Antimicrobial susceptibility of Streptococcus pneumoniae in adult patients with pneumococcal pneumonia in an urban hospital in Mozambique

被引：7

作者：

Bos J.C. ^{[1
,5
]}

Beishuizen S.J. ^{[2
]}

Madeira G.C. ^{[6
]}

Gomonda E.D.S. ^{[6
,7
]}

Cossa E.O. ^{[7
]}

Macome A.C. ^{[7
]}

Van Steenwijk R.P. ^{[4
]}

Schultsz C. ^{[3
,5
]}

Prins J.M. ^{[1
]}

机构：

[1] Department of Internal Medicine, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, 1105 AZ

[2] University of Amsterdam (UvA), Faculty of Medicine, 1105 AZ, Amsterdam

[3] Department of Medical Microbiology, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam

[4] Department of Pulmonology, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam

[5] Amsterdam Institute for Global Health and Development (AIGHD), Trinity Building C, Amsterdam, 1105 BM

[6] Faculdade de Ciências de Saúde, Universidade Católica de Moçambique (UCM), Beira

[7] Hospital Central da Beira (HCB), Beira

来源：

BMC Research Notes | / 7卷 / 1期

关键词：

Adults; Antimicrobial susceptibility; Penicillin resistance; Pneumonia; Streptococcus pneumoniae; Sub-Saharan Africa;

D O I：

10.1186/1756-0500-7-110

中图分类号：

学科分类号：

摘要：

Background: Streptococcus pneumoniae is the leading cause of community-acquired pneumonia in Africa. Antimicrobial resistance of S. pneumoniae to penicillin and other commonly used antibiotics has increased worldwide. However, prevalence data from the African region are sparse, especially with regard to adults. Findings. In this study, adult patients presenting at an urban referral hospital in central Mozambique were screened for pneumococcal pneumonia during an 8-week period in 2010: Patients with a respiratory syndrome underwent chest radiography and a sputum sample was collected for pneumococcal culture and antimicrobial susceptibility testing. A urine sample was tested for the presence of pneumococcal antigen.177 patients with a respiratory syndrome were included. Overall, 41/177 (23%) patients fulfilled criteria for definite or probable pneumococcal pneumonia and in the group of patients with a positive chest x-ray this concerned 35/86 (41%) patients. 166 sputum cultures yielded 16 pneumococcal strains. One mg oxacillin disc testing identified potential penicillin resistance in 7/16 (44%) strains. Penicillin minimal inhibitory concentrations (MICs) were measured for 15 of these strains and ranged from <0.016-0.75 mg/L. No MICs >2 mg/L were found, but 3/15 (20%) pneumococcal strains had MICs >0.5 mg/L. All pneumococci were sensitive to erythromycin as measured by disc diffusion testing, whereas 44% was resistant to trimethoprim-sulfametoxazole. Conclusions: The proportion of pneumonia cases attributable to pneumococcus appeared to be high. Whilst none of the S. pneumoniae strains tested were penicillin resistant, standard penicillin dosing for pneumonia may be insufficient given the observed range of pneumococcal penicillin MICs. © 2014 Bos et al.; licensee BioMed Central Ltd.

引用

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