Effect of adrenalectomy on the slimming activity of liposome-carried oleoyl-estrone in the rat

被引：10

作者：

Grasa M.M. ^{[1
,2
]}

Cabot C. ^{[1
,2
]}

Adán C. ^{[1
,2
]}

Vilà R. ^{[2
]}

Esteve M. ^{[1
,2
]}

Estruch J. ^{[1
]}

Fernández-López J.A. ^{[2
]}

Remesar X. ^{[2
]}

Alemany M. ^{[2
,3
]}

机构：

[1] Ctr. d'Investigacio Laboratoris, SALVAT, SA, Esplugues deLlobregat Barcelona

[2] Dept. de Bioquim. i Biol. Molecular, Facultat de Biologia, Universitat de Barcelona

[3] Dept. de Bioquim. i Biol. Molecular, Facultat de Biologia, Universitat de Barcelona, Av. Diagonal, 645

来源：

International Journal of Obesity | 1998年 / 22卷 / 12期

关键词：

Adrenalectomy; Glucocorticoids; Leptin; Obesity; Oleoyl-estrone; Slimming;

D O I：

10.1038/sj.ijo.0800751

中图分类号：

学科分类号：

摘要：

OBJECTIVE: To determine the extent of glucocorticoid counter-regulatory control in the slimming action of oleoyl-estrone. DESIGN: Control and adrenalectomized rats were subjected to a seven-day treatment with 3.5 μmol/kg/d oleoyl-estrone in liposomes injected i.v. continuously by implanted osmotic minipumps. SUBJECTS: Sham-operated control and adrenalectomized lean Zucker rats. MEASUREMENTS: Body weight and food intake; plasma glucose, urea, insulin, leptin and corticosterone; liver glycogen. RESULTS: Treatment with oleoyl-estrone resulted in decreases in body weight and in food intake, as well as in circulating glucose, insulin and leptin. Combined adrenalectomy and oleoyl-estrone treatment resulted in a loss of almost 15% body weight in only seven days, with a severe drop in circulating glucose and insulin, almost total disappearance of plasma leptin and liver glycogen and a 3-fold rise in circulating urea. Food intake decreased sharply, which resulted in the exhaustion of energy reserves. CONCLUSION: The results presented here, strongly support the hypothesis that glucocorticoids play an important role in the modulation of oleoyl-estrone-induced imbalance of energy intake and expenditure. The large effect of oleoyl-estrone on glucose, glycogen- and protein-derived (urea levels) energy in adrenalectomized rats, provides more evidence for the assumed protective role of glucocorticoids against the oleoyl-estrone-induced net loss of energy reserves. The results also show the powerful destabilizing effects of unchecked oleoyl-estrone on energy balance.

引用

页码：1225 / 1230

页数：5

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