Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?

被引：194

作者：

Koh L. ^{[1
]}

Zakharov A. ^{[1
]}

Johnston M. ^{[1
]}

机构：

[1] Neuroscience Program, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M4N 3M5

来源：

Cerebrospinal Fluid Research | / 2卷 / 1期

关键词：

Olfactory Bulb; Lymphatic Vessel; Cervical Lymph Node; Subarachnoid Space; Olfactory Nerve;

D O I：

10.1186/1743-8454-2-6

中图分类号：

学科分类号：

摘要：

In most tissues and organs, the lymphatic circulation is responsible for the removal of interstitial protein and fluid but the parenchyma of the brain and spinal cord is devoid of lymphatic vessels. On the other hand, the literature is filled with qualitative and quantitative evidence supporting a lymphatic function in cerebrospinal fluid (CSF) absorption. The experimental data seems to warrant a re-examination of CSF dynamics and consideration of a new conceptual foundation on which to base our understanding of disorders of the CSF system. The objective of this paper is to review the key studies pertaining to the role of the lymphatic system in CSF absorption. © 2005 Koh et al; licensee BioMed Central Ltd.

引用

共 109 条

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