Expression of transforming growth factor-β and insulin-like growth factor in molar and placental tissues

被引：17

作者：

Zhan-Jun Pang

Fu-Qi Xing

机构：

[1] Department of Obstetrics, Nanfang Hospital

来源：

Archives of Gynecology and Obstetrics | 2003年 / 269卷 / 1期

关键词：

Hydatidiform mole; Insulin-like growth factor; Placenta; Preeclampsia; Transforming growth factor-β;

D O I：

10.1007/s00404-002-0379-3

中图分类号：

学科分类号：

摘要：

The semiquantitative reverse transcription polymerase chain reaction was employed to detect the expression of transforming growth factor β (TGF-β) and insulin-like growth factor (IGF) in complete hydatidiform mole, normal first-trimester villi, the normal term placenta (after vaginal/ abdominal deliver) and the preeclamptic placenta at term. The expression of IGF-I mRNA was seen in all five tissues, but its level was much lower in the term placental tissues with preeclampsia than in other tissues. The content of IGF-I mRNA in villous tissues from molar pregnancy was slightly higher than in normal first-trimester villi. IGF-II mRNA was detected at similar levels in all three sorts of term placental tissues. However, the expression level of IGF-II mRNA in tissues of complete molar pregnancy was significantly lower than in normal first-trimester villi. TGF-β3 was found expressed in all five tissues, while TGF-β1 and TGF-β2 mRNA were not detected. Compared to the normal first-trimester villi, the expression of TGF-β3 in complete hydatidiform molar tissues was comparatively higher. Furthermore, the expression levels of TGF-β3 in the preeclamptic placenta and the normal placenta after cesarean birth were higher than in the placenta after vaginal delivery. We concluded that, the change of TGF-β and IGF expression in placental tissues might be involved in the development of trophoblastic diseases of pregnancy.

引用

页码：1 / 4

页数：3

共 16 条

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