Drug-induced diarrhea

被引：37

作者：

Abraham B. ^{[1
]}

Sellin J.H. ^{[1
]}

机构：

[1] University of Texas Medical Branch, Galveston, TX 77555-0764

来源：

Current Gastroenterology Reports | 2007年 / 9卷 / 5期

关键词：

Diarrhea; Orlistat; Loperamide; Chenodeoxycholic Acid; Motilin;

D O I：

10.1007/s11894-007-0044-x

中图分类号：

学科分类号：

摘要：

Many drugs have been known to cause diarrhea, although their mechanism of action has not been well described. The gastrointestinal tract may become dysregulated when exposed to a drug that could disrupt mechanisms controlling mucosal permeability, transport, motility, and gut metabolism. This review examines the mechanism by which drugs induce diarrhea within the broad classification of watery, inflammatory, and fatty characteristics of the stool. Treatment may vary depending on this classification and usually includes withdrawal of the offending drug. However, in some cases, diarrhea may resolve with continued use or through nonspecific agents, such as Lomotil (Pfizer, New York, NY) or loperamide. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：365 / 372

页数：7

共 47 条

[1]

Chassany O., Michaux A., Bergmann J.F., Drug-induced diarrhoea, Drug Safety, 22, pp. 53-72, (2000)

[2]

Schiller L.R., Sellin J.H., Diarrhea, Gastrointestinal and Liver Disease, pp. 159-181, (2006)

[3]

Ratnaike R.N., Jones T.E., Mechanisms of drug-induced Diarrhoea in the elderly, Drugs Aging, 13, pp. 245-253, (1998)

[4]

Pasricha P.J., Treatment of disorders of bowel motility and water flux

[5]

antiemetics: Agents used in biliary and pancreatic disease, Goodman & Gilman's The Pharmacological Basis of Therapeutics, pp. 983-1008, (2006)

[6]

Binder H.J., The gastroenterologist's osmotic gap: Fact or fiction?, Gastroenterology, 103, pp. 702-704, (1992)

[7]

PDR Health: Prebiotics

[8]

Marteau P., Seksik P., Tolerance of probiotics and prebiotics, J Clin Gastroenterol, 38, (2004)

[9]

Plass H., Charisius M., Wyskovsky W., Et al., Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium, Arch Pharmacol, 371, pp. 492-499, (2005)

[10]

Crowell M.D., Harris L.A., DiBaise J.K., Olden K.W., Activation of type-2 chloride channels: A novel therapeutic target for the treatment of chronic constipation, Curr Opin Invest Drugs, 8, pp. 66-70, (2007)

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