Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium

被引：79

作者：

Martens T.P. ^{[1
]}

See F. ^{[1
]}

Schuster M.D. ^{[1
]}

Sondermeijer H.P. ^{[1
]}

Hefti M.M. ^{[1
]}

Zannettino A. ^{[3
]}

Gronthos S. ^{[3
]}

Seki T. ^{[2
]}

Itescu S. ^{[2
]}

机构：

[1] Division of Cardiothoracic Surgery, Columbia University, New York, NY 10032

[2] Department of Surgery, Columbia University, New York, NY 10032

[3] Myeloma and Mesenchymal Research Laboratory, Division of Haematology, Hanson Institute, Adelaide, SA

来源：

Nature Clinical Practice Cardiovascular Medicine | 2006年 / 3卷 / Suppl 1期

关键词：

Cardiac myogenesis; Cardiac neovascularization; Mesenchymal precursor cells; STRO-1; VCAM1;

D O I：

10.1038/ncpcardio0404

中图分类号：

学科分类号：

摘要：

Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery. © 2006 Nature Publishing Group.

引用

页码：S18 / S22

页数：4

共 13 条

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